Receptor membranes

Details Receptor membranes Receptor membranes

1995-05-23

1998-04-21

Housel, James C.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 71, 435817, 436512, 436518, G01N 3353, G01N 33543, G01N 33563, G01N 33566

Patent

active

057417121

ABSTRACT:
The present invention provides a biosensor that detects an analyte in a sample by measuring the response of a membrane within which associated ion channels undergo state changes upon interaction between the analyte and the ionic channels. The state change response is detected as result of the change in ionic flow through the membrane.

REFERENCES:
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patent: 4517303 (1985-05-01), Freytag et al.
patent: 4661235 (1987-04-01), Krull et al.
patent: 4758342 (1988-07-01), Heckmann et al.
patent: 5443955 (1995-08-01), Cornell et al.
Williams, D.E., "Electrochemical Noise" and Chemical Sensing, Materials Development Division Harwell Laboratory, (One day conference in Boston, Mass., Nov. 9, 1987), pp. 203-208.
Huang, et al., Interactions of Immunoliposomes with Target Cells, The Journal of Biological Chemistry, No. 22, Issue of Nov. 22, pp. 14034-1440, 1983.

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