Receptor-mediated delivery system

Details Receptor-mediated delivery system Receptor-mediated delivery system

1990-09-14

1992-07-14

Rosenbaum, C. Fred

Surgery

Magnetic field applied to body for therapy

Magnetic element placed within body

424450, A61M 3700, A61K 3722

Patent

active

051298775

ABSTRACT:
A delivery system for biologically active materials consisting of polysaccharide or polypeptide microspheres which bind to glycosaminoglycan receptors on cell surfaces. The delivery system can be used to localize drugs by both biochemical and physical means. In one embodiment, microspheres prepared from the polysaccharide chitosan are bound to anionic polysaccharides similar to the glycosaminoglycan receptors found on the surface of capillary endothelial cells. The microspheres were formulated to have a controlled cationic character, and had a mean diameter of 0.70 u and a magnetite content of 16% w/w. Binding to a model polysaccharide, heparin, was demonstrated in vitro. Binding to cultured cerebral capillary endothelial cells was also demonstrated.

REFERENCES:
patent: 3474777 (1969-10-01), Figge et al.
patent: 4157323 (1979-06-01), Yen et al.
patent: 4285819 (1981-08-01), Yen et al.
patent: 4331654 (1982-05-01), Morris
patent: 4501726 (1985-02-01), Schroder et al.
patent: 4582622 (1986-04-01), Ikeda et al.
patent: 4612247 (1986-09-01), Walsh et al.
patent: 4637929 (1987-01-01), Quay
patent: 4639364 (1987-01-01), Hoey
patent: 4647447 (1987-03-01), Gries et al.
patent: 4647536 (1987-03-01), Mosbach et al.
patent: 4652257 (1987-03-01), Chang
patent: 4656026 (1987-04-01), Coffman et al.
patent: 4669481 (1987-06-01), Eisenberg et al.
patent: 4687748 (1987-08-01), Schroder
patent: 4713249 (1987-12-01), Schroder
patent: 4758422 (1988-07-01), Quay
patent: 4772475 (1988-09-01), Fukui et al.
patent: 4803168 (1989-02-01), Garvis, Jr.
patent: 4827945 (1989-05-01), Groman et al.
patent: 4853226 (1989-08-01), Machida et al.
Zubay, Geoffrey, Biochemistry, (1983), pp. 645-656.
Widder et al., Proc. Soc. Exper. Biol. Med., 58, 141-146 (1978).
Allan et al., "Biomedical Applications of Chitin and Chitosan", pp. 119-113, Chitin, Chitosan and Related Enzymes, (Academic Press, Inc., New York, 1984).
Nagai, et al., "Application of Citin and Chitosan to Pharmaceutical Preparations", pp. 21-39, Chitin, Chitosan and Related Enzymes, (Academic Press, Inc., New York, 1984).
Audus and Borchardt, Bioreversible Carriers in Drug Design, 27-47, (E. B. Roche, Pergamon Press, New York, 1986).
Audus and Borchardt, Am. J. Pathol., 103, 353-366 (1981).
Gallo and Hassan, Pharm. Res., 5, 300-304, (1988), (not prior art).

Affiliated with

Also associated with

Rating

Receptor-mediated delivery system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Receptor-mediated delivery system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Receptor-mediated delivery system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-332134