Receptor-ligand system and assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S007210, C435S069100, C435S070100, C435S173300, C435S235100, C435S325000, C435S375000, C435S320100, C530S300000, C530S350000, C536S023100, C536S023500

Reexamination Certificate

active

07037662

ABSTRACT:
An Eph family RTK (receptor tyrosine kinase) ligand-binding domain as well as a method of identifying Eph family RTK agonists or antagonist. The ligand-binding domain is suitably encoded by exon III of a gone encoding the RTK of the Eph family and may additionally include an amino acid sequence encoded by exon II of the gene. The ligand-binding domain may be a polypeptide having amino acids 57-271 of the sequence shown in FIG. 1.

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patent: WO 93/00425 (1993-01-01), None
George et al., Current Methods in Sequence Comparison and Analysis, Macromolecular Sequencing and Synthesis, Selected Methods asd Applications. Edited by David H. Schlesinger, Alan R. Liss, In., New York. pp. 124-149, 1988.
Andrew W. Boyd, Larry D. Ward, Ian P. Wicks, Richard J. Simpson, Evelyn Salvaris, Andrew Wilks, Karen Welch, Maureen Loudovaris, Steven Rockman, Inese Busmanis;Isolation and Characterization of a Novel Receptor-type Protein Tyrosine Kinase(hek)from a Human Pre-B Cell Line; The Journal of Biological Chemistry; vol. 267, No. 5, Feb. 15, 1992; pp. 3262-3267.
I. P. Wicks, D. Wilkinson, E. Salvaris, A.W. Boyd;Molecular Cloning of HEK, the Gene Encoding a Receptor Tyrosine Kinase Expressed by Human Lymphoid Tumor Cell Lines; Proc. Natl. Acad. Sci., vol. 89, Mar. 1992, pp. 1611-1615.
Ian P. Wicks, Naras M. Lapsys, Elizabeth Baker, Lynda J. Campbell, Andrew W. Boyd, Grant R. Sutherland;Localization of a Human Receptor Tyrosine Kinase(ETK1)to Chromosome Region 3p11.2; Genomics; vol. 19, 1994, pp. 38-41.

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