Receptor derived peptides involved in inhibition of receptor int

Details Receptor derived peptides involved in inhibition of receptor int Receptor derived peptides involved in inhibition of receptor int

1996-03-08

1999-09-14

Feisee, Lila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 514 13, 514 14, 514 15, 514 16, 435 721, 530300, 530324, 530325, 530326, 530327, 530328, 530350, A61K 3804, A61K 3816, C07K 14705, C07K 1474

Patent

active

059522933

ABSTRACT:
Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

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