Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-01-18
2011-01-18
Weddington, Kevin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S419000, C514S880000, C514S929000
Reexamination Certificate
active
07872040
ABSTRACT:
It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine.The present invention relates to a pharmaceutical or food composition for α2receptor blockage comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof:(wherein R1represents a hydrogen, alkyl group, alkenyl group, alkynyl group, aromatic group, aralkyl group, acyl group, arylsulfonyl group, alkylsulfonyl group, or hydroxyl group; R2represents a hydrocarbon group; R3, R4, R5, R6, and R7are the same or different and represent a hydrogen, halogen, alkyl group, or alkoxy group; R8represents a hydrogen or acyl group; n represents an integer of 1 to 6; and a and b are the same or different and represent 1 or 0).
REFERENCES:
patent: 4087444 (1978-05-01), Flaugh et al.
patent: 4614807 (1986-09-01), Flaugh
patent: 5272141 (1993-12-01), Fraschini et al.
patent: 5276051 (1994-01-01), Lesieur et al.
patent: 5308866 (1994-05-01), Lesieur et al.
patent: 5380750 (1995-01-01), Lesieur et al.
patent: 5430029 (1995-07-01), Fraschini et al.
patent: 5481021 (1996-01-01), Garland et al.
patent: 5552428 (1996-09-01), Fraschini et al.
patent: 6281241 (2001-08-01), Elsner
patent: 6730707 (2004-05-01), Pintor et al.
patent: 2007/0197629 (2007-08-01), Somei et al.
patent: 2242091 (1975-03-01), None
patent: 52-57169 (1977-05-01), None
patent: 5-155769 (1993-06-01), None
patent: 6-505497 (1994-06-01), None
patent: 6-183968 (1994-07-01), None
patent: 6-199784 (1994-07-01), None
patent: 6-263635 (1994-09-01), None
patent: 7-112970 (1995-05-01), None
patent: 2003-519181 (2003-06-01), None
patent: 2004-500353 (2004-01-01), None
patent: WO-9215607 (1992-09-01), None
patent: WO-0139771 (2001-06-01), None
patent: WO-01/49286 (2001-07-01), None
patent: WO-02-071873 (2002-09-01), None
patent: WO-03/068743 (2003-08-01), None
patent: WO-2005/084664 (2005-09-01), None
Girouard et al., “Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats”, Journal of Hypertension, vol. 19, No. 8, pp. 1369-1377 (Aug. 2001).
Rasmussen et al., “Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels”, Endocrinology, vol. 140, No. 2, pp. 1009-1012 (Feb. 1999).
Drago et al., “Acute low doses of melatonin restore full sexual activity in impotent male rats”, Brain Research, vol. 878, No. 1-2, pp. 98-104 (Sep. 2000).
Science Daily (www.sciencedaily.com/releases/2001/02/010215074636). Blood Vessels Hold Key To Thicker Hair Growth (2001).
Roth, J.A. et al.; J. Biol. Cheml, vol. 274, No. 31, pp. 22041-22047 (1999).
Somei, Masanori et al.; Heterocycles, vol. 53, No. 8, pp. 1725-1736 (2000).
Suzuki, Nobuo et al.; Journal of Pineal Research, vol. 33, pp. 253-258 (2002).
Shigenobu Koki
Somei Masanori
Tanaka Yoshio
Birch & Stewart Kolasch & Birch, LLP
Weddington Kevin
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