Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-21
2006-03-21
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007930, C435S007940, C435S007950, C436S517000, C436S518000
Reexamination Certificate
active
07015003
ABSTRACT:
Improved receptor assays for the detection of thyroid stimulating hormone receptor (TSHR) autoantibodies are described which use immobilized, affinity-purified rTSHR preparations as specific binders. This format, as well as novel measures for neutralizing pathologically increased human TSH (hTSH) levels in the sera, e.g., by the addition of anti-hHSH antibody, and/or eliminating the influence of anti-bovine TSH antibody, result in increased assay reliability and open up the possibility of preparing the assay constituents in a ready to use and/or well-standardized form for automatic processing and/or convenient marketing.
REFERENCES:
patent: 5614363 (1997-03-01), Cone et al.
patent: 5814461 (1998-09-01), Bergmann et al.
patent: 95/06258 (1995-03-01), None
patent: WO-95/06258 (1995-03-01), None
patent: 98/26294 (1998-06-01), None
Morgenthaler NG et al, Binding of antithyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro translated thyrotropin receptor: ability to map epitopes, Feb. 1996, J Clin Endocrinol Metab 81(2):700-6.
Morris JC., Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides, May 1993, J Biol Chem 268(15):10900-5.
Stryer et al, 1988, in Biochemistry, Third Edition, W. H. Freeman and Company/New York, pp. 31-33.
Harlow et al, 1988, in Antibodies A Laboratory Manual, p. 25-26, pp. 553-593.
Kuby et al, 1994, Immunology, Second edition, pp. 86-96.
Colman et al, 1994, A structural view of immune recognition by antibodies, pp. 33-36.
Vitti et al, Acta Med Austriaca 23(1-2): 52-6, 1996.
Nicholson et al, J Mol Endocrinol 16(2): 159-70, 1996.
Chemical Abstracts, vol. 127, No. 1, Jan. 5, 1998 Columbus, Ohio US; Abstract No. 679865 XP002103277 siehe Zusammenfasung & W.B. Minich et al.: “Expression of a functional tagged human thyrotropin receptor in hela cells using recombinant vaccinia virus” Experimental and Clinical Endocrinology and Diabetes, Bd. 105, Nr. 5, 1997, Seiten 282-290 New York NY USA.
Bergmann Andreas
Hollidt Jörg-Michael
Morgenthaler Nils
Struck Joachim
Weglöhner Wolfgang
B.R.A.H.M.S Aktiengesellschaft
Chan Christina
Huynh Phuong
Mayer Brown Rowe & Maw LLP
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