Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-02-05
1996-04-30
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 691, 435965, 935 60, 935 80, 935 81, 935108, C12Q 168
Patent
active
055124356
ABSTRACT:
Methods and composition are provided for identifying antiproliferative polypeptides which inhibit clonal expansion and/or induce apoptosis in cells of a predetermined cell population (e.g., a neoplastic cell sample) expressing a cell surface receptor which is a member of the immunoglobulin superfamily. A predetermined cell population expressing surface immunoglobulin superfamily molecules is isolated from a patient as a cellular sample, such as a lymph node biospy or blood sample containing neoplastic lymphocytic cells. Antiproliferative peptides which are identified by the methods of the invention can be used as therapeutic agents for treating lymphoproliferative disorders by anti-idiotype therapy.
REFERENCES:
patent: 5227159 (1993-07-01), Miller
George et al., Monoclonal Antibodies Raised Against the Idiotype of the Murine B Cell Lymphoma, BCL.sub.1 Act Primarily with Heavy Chain Determinants, Hybridoma 10:219-227 (1991).
Hata et al., Tyrosine Phosphorylaiton of IqM-and IqD-Associated Molecules of a Human B Lymphoma Cell Line B104, International Immunology 4:797-804 (1992).
Lam K.S., Treatment of a B-Cell Lymphoma Using Peptides a Novel Concept, the Western Journal of Medicine 158:475-479 (1993).
Renschler and Levy, Overcoming the Limitations of Chemotherapy in the Treatment of B-Cell Non-Hodgkin's Lymphomas--An Approach Using Radiolabeled Peptide Ligands, the Western Journal of Medicine 158:530-532 (1993).
Smith et al., Production of Heterologous Antibodies Specific for Murine B-Cell Leukemia Immunoglobulin by Immunization with Synthetic Peptides Homologous to Heavy Chain Hypervariable Regions, Cancer Research 45:6119-6123 (1985).
Thielemans et al., Syngeneic Antidiotypic Immune Respones to A B Cell Lymphoma, J. Exp. Med. 162:19-34 (1985).
Levy et al., Therapy of Lymphana Directed at Idio Types, J. Natl Cancer Inst Monographs 10: 61-68, 1990.
Bhatt Ramesh R.
Dower William J.
Levy Ronald
Renschler Markus F.
Dunn Tracy J.
Scheiner Toni R.
Wortman Donna C.
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