Receptor-based screening methods for amylin agonists and antagon

Details Receptor-based screening methods for amylin agonists and antagon Receptor-based screening methods for amylin agonists and antagon

1991-03-15

1993-11-23

Nucker, Christine M.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436501, 436503, G01N 33566, G01N 33567

Patent

active

052643727

ABSTRACT:
Methods for identifying or screening or characterizing or assaying or isolating known or candidate agonists and antagonists of amylin, comprising binding assays utilizing preparations containing specific receptors for amylin. Membranes from the brain that contain high density receptors for amylin are particularly useful for the methods of this invention, and as a source of amylin receptors.

REFERENCES:
patent: 4434236 (1984-02-01), Freytag
Morishita et al (1990 Jul.) Diabetes 39:875-877.
Stephens et al (1991 Mar.) Diabetes 40:395-400.
Sayema et al (1975) Fertility & Sterility 26:397-404.
Clark et al (1987) Lancet 8554:231-234.
Leighton et al (1988) Nature 335:632-635.
Sanke et al (1988) J. Biol Chem 263:17243-17246.
Leighton et al (1990) Biochem J 269:19-23.
Leighton et al (1990) TIBS 15:295-299.
Cooper et al., Proc. Nat'l Acad. Sci. USA 84:8628-32 (1987).
Cooper et al., Prog. Growth Factor Research 1:99-104 (1989).
Rosenfeld et al., Nature 304--129-35 (1983).
Amara et al., Science 229--1094-97 (1985).
Leighton et al., Nature 335:632-35 (1988).
Young et al., Amer. J. Physiol. 259:E457-61 (1990).
Leighton et al., Biochem. J. 269:19-23 (1990).
Young et al., FEBS 281:149-51 (1991).
Molina et al., Diabetes 39:260-65 (1990).
Koopmans et al., Diabetes 39:101A (1990).
Ciaraldi et al., Diabetes 39:145A (1990).
Brain et al., Amer. J. Pathol. 136:487-90 (1990).
Datta et al., Biochem. Biophys. Res. Commun. 162:876-80 (1989).
Chantry et al., Biochem. J. 277:139-43 (1991).
Banks, Journal of NIH Research 2:34-35 (1990).
Banks, Diabetes Forecast 44:26-31 (1991).
Tschopp et al., Proc. Nat. Acad. Sci. USA 82:248-52 (1985).
Sexton et al., Neuroscience 19:1235-45 (1986).
Goltzman et al., Science 227--:1343-45 (1985).
Sexton et al., Kidney Int. 32:862-68 (1987).
Sexton et al., Neurochem. Int. 12:323-35 (1988).
Dennis et al., Soc. Neurosci. Abs. 16:514 (1990).
Galeazza et al., Peptides 12:585-91 (1991).
Dennis et al., Journal of Pharmacology and Experimental Therapeutics 251:718-725 (1989).
Dennis et al., Journal of Pharmacology and Experimental Therapeutics 254:123-128 (1990).
Dennis et al., Brian Research 539--59-66 (1991).
Trends in Pharmacological Sciences Receptor Nomenclature Supplement:10 (Jan. 1992).

Affiliated with

Also associated with

Rating

Receptor-based screening methods for amylin agonists and antagon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Receptor-based screening methods for amylin agonists and antagon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Receptor-based screening methods for amylin agonists and antagon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1848409