Receptor-based interaction trap

Details Receptor-based interaction trap Receptor-based interaction trap

2002-11-22

2010-12-21

Bunner, Bridget E (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007200, C435S325000, C435S254110, C435S419000, C536S023400

Reexamination Certificate

active

07855270

ABSTRACT:
The present invention discloses a recombinant receptor comprising an extracellular ligand-binding domain and a cytoplasmic domain that comprises a heterologous bait polypeptide. The recombinant receptor is activated by binding of a ligand to the ligand binding domain and by binding of a prey polypeptide to the heterologous bait peptide. The present invention also discloses a method for detecting compound-compound binding using the recombinant receptor.

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