Receptor-based interaction trap

Details Receptor-based interaction trap Receptor-based interaction trap

2011-08-23

2011-08-23

Bunner, Bridget E (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007200, C435S325000, C435S254110, C435S419000

Reexamination Certificate

active

08003757

ABSTRACT:
Described is a recombinant receptor comprising an extracellular ligand-binding domain and a cytoplasmic domain that comprises a heterologous bait polypeptide. The recombinant receptor is activated by binding of a ligand to the ligand-binding domain and by binding of a prey polypeptide to the heterologous bait peptide. The invention also discloses a method for detecting compound-compound binding using the recombinant receptor.

REFERENCES:
patent: 5521066 (1996-05-01), Menzel et al.
patent: 5686281 (1997-11-01), Roberts
patent: 5716622 (1998-02-01), Darnell et al.
patent: 5744314 (1998-04-01), Menzel et al.
patent: 5776689 (1998-07-01), Karin et al.
patent: 5843697 (1998-12-01), Pestka et al.
patent: 5885779 (1999-03-01), Sadowski et al.
patent: 5935797 (1999-08-01), Clayberger et al.
patent: 5972621 (1999-10-01), Tartaglia et al.
patent: 6001816 (1999-12-01), Morsy et al.
patent: 6270964 (2001-08-01), Michnick et al.
patent: 6294330 (2001-09-01), Michnick et al.
patent: 6303319 (2001-10-01), Rickles
patent: 6342345 (2002-01-01), Blau et al.
patent: 6734006 (2004-05-01), Xiao et al.
patent: 7575878 (2009-08-01), Tavernier et al.
patent: 2001/0023062 (2001-09-01), Ostade et al.
patent: 0 646 644 (1995-04-01), None
patent: WO 97/00319 (1997-01-01), None
patent: WO 97/20933 (1997-06-01), None
patent: WO97/26335 (1997-07-01), None
patent: WO 97/31113 (1997-08-01), None
patent: WO 97/46585 (1997-12-01), None
patent: WO 98/02542 (1998-01-01), None
patent: WO 98/12224 (1998-03-01), None
patent: WO 98/20158 (1998-05-01), None
patent: WO 98/34120 (1998-08-01), None
patent: WO 98/44350 (1998-10-01), None
patent: WO 99/03974 (1999-01-01), None
patent: WO 99/40946 (1999-08-01), None
patent: WO 00/06722 (2000-02-01), None
patent: WO 00 07014 (2000-02-01), None
patent: WO 00/07038 (2000-02-01), None
patent: WO 02/40543 (2002-05-01), None
patent: WO 02/062833 (2002-08-01), None
Banks et al., Activiation of Downstream Signals by the Long Form of the Leptin Receptor, Journal of Biological Chemistry, May 12. 2000, pp. 14563-14572, vol. 275. No. 19, U.S.A.
Bannasch et al., Oncogene, 1999, pp. 6810-6817. vol. 18.
Bao et al., Oncogene, 1996, pp. 2171-2176, vol. 12.
Baumann et al., Proc. Natl. Acad. Sci. USA, 1996, pp. 8374-8378, vol. 93.
Beattie et al., Obesity and Hyperleptinemia in Metallothionein (-I and -II) Null Mice. Proceedings of the National Academy of Sciences of USA, Jan. 1998, pp. 358-363, vol. 95.
Bjorbaek et al., Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance, Molecular Cell, Mar. 1998, pp. 619-625, vol. 1, No. 4.
Bjorbaek et al., The Role of SOCS-3 in Leptin Signaling and Leptin Resistance, The Journal of Biological Chemistry, Oct. 15, 1999, pp. 30059-30065, vol. 274, No. 42.
Bonnefoy-Berard et al., “Vav: Function and Regulation in Hematopoietic Cell Signaling.” 14 Stem Cells 250-68 (1996).
Campfield et al., Science. 1998, pp. 1383-1389, vol. 280.
Carpenter et al., Proc. Natl Acad Sci USA. 1998. pp. 6061-6066, vol. 95.
Colas et al., The impact of two-hybrid and related methods on biotechnology, Trends in Biotechnology, Aug. 1998, pp. 355-363, vol. 16.
Daly et al., Recognition of human colon cancer by T cells transduced with a chimeric receptor gene, Cancer Gene Therapy, 2000, pp. 284-291, vol. 7, No. 2.
David et al., J. Biol. Chem. 1996, pp. 4585-4588, vol. 271.
Dusetti et al., Abstract, Structural organization of the gene encoding the rat pancreatitis-associated protein, Jul. 5, 1993, pp. 14470-14475, vol. 268.
Dusetti et al., The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene whose expression is up-regulated during pancreatic inflammation, Feb. 28, 1997, pp. 5800-5804.
Estojak et al., 1995, Molecular and Cellular Biology, pp. 5820-5829, vol. 15, No. 10.
Eyckerman et al., Analysis of Tyr to Phe and fa/fa leptin receptor mutations in the PC12 cell line, Eur. Cytokine Netw, Dec. 1999. pp. 549-556, vol. 10. No. 4.
Eyckerman et al., Design and application of a cytokine-receptor-based interaction trap, Nature Cell Biology. Dec. 2001, pp. 1114-1119, vol. 3.
Fields et al., The two-hybrid system: an assay for protein-protein interactions, Trends in Genetics, Aug. 1994, pp. 286-292, vol. 10, No. 8.
Fujiwara et al., Biochemistry, 2002, pp. 12729-12738, vol. 1, No. 42.
Ghilardi et al., Proc. Natl. Acad. Sci. USA, 1996, pp. 6231-6235, vol. 93.
Gisselbrecht, Sylvie, The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling. 10(4) European Cytokine Network 463-470 (Dec. 1999). retrieved from <URL:http://www.john-libbey-eurotest.fr/articles/ccn/10/4/463-70/> Jul. 12, 2001.
Grasso et al., Endocrinol. 1997, pp. 1413-1418, vol. 138.
Hertveldt et al., Identification of Ga180p-interacting proteins bySaccharomyces cerevisiaewhile genome phage display, Gene, 2003, pp. 141-149, vol. 307.
Hilpert et al., Protein Engineering, 2001, pp. 803-806 (11 pages as printed) vol. 14, No. 10.
Ihle et al., Abstract. Jaks and Stats in signaling by the cytokine receptor superfamily, Trends Genet., Feb. 1995, pp. 69-74, vol. 11, No. 2.
Iyengar, FASEB J., 1993, pp. 768-775, vol. 7.
Junqueira et al., Oncogene, 2003, pp. 2772-2781, vol. 22.
Lee et al., Abnormal splicing of the leptin receptor in diabetic mice, Nature, Feb. 15, 1996, pp. 632-635, vol. 379.
Medici et al., The EMBO Journal, 1997, pp. 7241-7249, vol. 16, No. 24.
Mercer et al., Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization, FEBS Letters, 1996, pp. 113-116, vol. 387.
Montoye et al., Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy, FEBS Letters, 2006, pp. 3301-3307, vol. 580.
Montoye et al., Blood, 2005, pp. 4264-4271, vol. 11, No. 105.
Montoye et al., In Press. A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian two-hybrid approach.
Murray et al., Journal of Immunology, 2007, pp. 2623-2629, vol. 5.
Nakashima et al., FEBS, 1997, pp. 79-82, vol. 403.
Ngo et al., The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox. Mar. 2, 1994, pp. 492-495.
Okuda et al., Ann N Y Acad Sci., 1999, pp. 305-312, vol. 872.
Osborne et al., The Yeats Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions. Biotechnology, Dec. 13, 1995, pp. 1474-1478, vol. 13.
Overton et al., Current Biology, 2000, pp. 341-344, vol. 10, No. 6.
PCT International Search Report, PCT/EP01/05916, dated Apr. 18, 2002, 3 pages.
Ray et al., J. Clin. Invest. 1996, pp. 1852-1859, vol. 97.
Record for GenBank Accession NM—14616,Mus musculusleptin receptor (Lepr), transcript variant 1. mRNA. printed Jan. 16, 2008.
Rohner-Jearnrenaud et al., The New Eng. J. Med., 1996, pp. 324-325, vol. 334.
Saitoh et al., Identification of Important Regions in the Cytoplasmic Justamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-beta. The Journal of Biological Chemistry, Feb. 2, 1996. pp. 2769-2775, vol. 271, No. 5.
Shores et al., Curr Opin Immunol., 1997, pp. 380-389, vol. 9, No. 3.
Stoffel et al., Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decision in vivo, Proc. Natl. Acad. Sci. Jan. 1999, pp. 698-702, vol. 96.
Tartaglia et al., Identification and Expression Cloning of a Leptin Receptor. OB-R, Cell. Dec. 29, 1995. pp. 1263-1271, vol. 83.
Vaisse et al., Leptin Activation of Stat3 in the Hypothalamus of Wild-Type and ob/ob Mice but not db/db Mice. Nature Genetics, Sep. 14, 1996, pp. 95-97, vol. 14.
Van Criekinge et al., Yeast Two-Hybrid: State of the Art, Biological Procedures Online, Oct. 4, 1999, vol. 2, No. 1, <www.biologicalprocedures.com>.
Wells, Additivity of Mutational Effects in Proteins, Biochemistry, Sep. 18, 1990, pp. 8509-8517, vol. 29, No. 37.
Zabeau et al., The ins and outs of leptin receptor activation, FEBS Letters, 2003, pp. 45-50, vol. 546.

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