Receptor antagonists and their methods of use

Details Receptor antagonists and their methods of use Receptor antagonists and their methods of use

2010-02-18

2011-11-01

Shameem, Golam M (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S530000, C548S537000, C514S408000, C514S424000

Reexamination Certificate

active

08048907

ABSTRACT:
The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptorand the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.

REFERENCES:
patent: 2651639 (1953-09-01), Angier
patent: 4772601 (1988-09-01), Martin
patent: 4933354 (1990-06-01), Ikeguchi et al.
patent: 6054579 (2000-04-01), Harriman
patent: 7718693 (2010-05-01), Walter
patent: 1385409 (2002-12-01), None
patent: 0 314 275 (1989-05-01), None
patent: 0 325 984 (1989-08-01), None
patent: 2273533 (1976-01-01), None
patent: WO 97/17958 (1997-05-01), None
patent: WO 99/00362 (1999-01-01), None
patent: WO 99/29661 (1999-06-01), None
patent: WO 99/29686 (1999-06-01), None
patent: WO 00/33788 (2000-06-01), None
patent: WO 2005/027882 (2005-03-01), None
patent: WO 2008/003697 (2008-01-01), None
Angier, Robert B. (1954): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 1954:68264.
Zhao et al.,Bioorganic&Medicinal Chemistry, 7(8), pp. 1647-1654 (1999).
Møss et al.,International Journal of Pharmaceutics, 52(3), pp. 255-263 (1989).
Tye et al.,Organic&Biomolecular Chemistry, vol. 2, pp. 813-815 (2004).
Harriman,Tetrahedron Letters, 38(32), pp. 5591-5594 (1997).
Bundgaard et al.,Biochemical Society Transactions, 17(5), pp. 947-949 (1989).
Bundgaard et al.,Journal of Pharmaceutical Sciences, 78(2), pp. 122-126 (1989).
Møss et al.,Acta Pharmaceutica Nordica, 4(4), pp. 301-308 (1992).
International Search Report for corresponding application PCT/EP2007/056675 (published as WO 08/003697A1).
Angier et al.,Journal of Organic Chemistry, 21(12), pp. 1540-1543 (1956).
Pharmaprojects Review (Jan. 2009) http://www.pharmaprojects.com/therapy—analysis/purin—P2X7—0109.htm.
Chemcats listing of CAS # 1001389-19-0 available from ChemDiv, Inc., San Diego, CA (Jul. 1, 2008).

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