Receptor activation with inactive hepatocyte growth factor ligan

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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4241941, 42419511, 530399, A61K 3818, C07K 14475

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active

057707049

ABSTRACT:
The invention concerns a method for activating receptors selected from receptor tyrosine kinases, cytokine receptors and members of the nerve growth factor receptor superfamily. A conjugate comprising the direct fusion of at least two ligands capable of binding to the receptor(s) to be activated is contacted with the receptors, whereby the ligands bind their respective receptors inducing receptor oligomerization.

REFERENCES:
patent: 4931548 (1990-06-01), Lucas et al.
patent: 4935233 (1990-06-01), Bell et al.
patent: 5100788 (1992-03-01), Lofdahl et al.
patent: 5108910 (1992-04-01), Curtis et al.
patent: 5227158 (1993-07-01), Jardieu
patent: 5334532 (1994-08-01), Tackney et al.
Ashkenazi et al., "Protection Against Endotoxic Shock by a Tumor Necrosis Factor Receptor Immunoadhesion" Proc. Natl. Acad. Sci. 88:10535-10539 (1991).
Ashkenazi, et al., "Comparative Study of in Vitro and in Vivo Modulation of Lactogenic and Somatotropic Receptors by Native Human Growth Hormone and Its Modified Analog Prepared by Recombinant Deoxyribonucleic Acid Technology" Endocrinology 121(1):414-419 (1987.
Becker et al., "Chemical physical, and biological characterization of a dimeric form of biosynthetic human growth hormone" Biotechnology and Applied Biochemistry 9:478-487 (1987).
Binder et al, "Site-directed mutations of human growth hormone that selectively modify its lactogenic activity and binding properties" Molecular Endocrinolgy 4(7):1060-1068 (1990).
Bottaro et al., "Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product" Science 251:802-804 (Feb. 15, 1991
Chan et al., "Glycine 119 of Bovine Growth Hormone is Critical for Growth-Promoting Activity" Molecular Endocrinology 5:1845 (1991).
Cunningham et al., "High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis" Science 244:1081-1085 (1989).
Cunningham et al., "Receptor and Antibody Epitopes n Human Growth Hormone Identified by Homolog-Scanning Mutagenesis" Science 243:1330-1336 (1989).
Cunningham et al., "Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule" Science 254:821-825 (1991).
Engelman et al., "Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity" Journal of Biological Chemistry 265:14497-14504 (1990).
Gertler et al., "Inhibition of Lactogenic Activities of Ovine Prolactin and Human Growth Hormone (hGH) by a Novel Form of a Modified Recombinant hGH" Endocrinology 118:720 (1986).
Gohda et al., "Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure" J. Clin. Invest. 81:414-419 (1988).
Hanks et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains" Science 241:42-52 (1988).
Heidaran et al., "Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB" Journal of Biological Chemistry 266:20232-20237 (1991).
Hernandez et al., "Characterization of the Effects of Human Placental HGF on Rat Hepatocytes" J. Cell Phys. 150(1):116-121 (1992).
Hoogenboom et al., "Construction and Expression of Antiobody-Tumor Necrosis Factor Fusion Proteins" Molecular Immunology 28:1027-1037 (1991).
Lokker et al., "Generation and Characterization of a Competitive Antagonist of Human Hepatocyte Growth Factor, HGF/NK1" Journal of Biological Chemistry 268(23) :17145-17150 (Aug. 15, 1993).
Mascarelli et al., "Heterocomplex formation betweeen high and low affinity FGF receptors is mediated by the formation of a FGF dimer" Bulletin du Cancer 80(9):786-798 (1993).
Miyazawa et al., "An Alternatively Processed mRNA Generated from Human Hepatocyte Growth Factor Gene" European Journal of Biochemistry 197:15-22 (1991).
Miyazawa et al., "Molecular Cloning and Sequence Analysis of cDNA for Human Hepatocyte Growth Factor" Biochem. & Biophys. Res. Comm. 163(2):967-973 (Sep. 15, 1989).
Munro, "Uses of chimaeric antibodies" Nature 312:597 (1984).
Nakamura et al., "Molecular Cloning and Expression of Human Hepatocyte Growth Factor" Nature 342:440-443 (Nov. 23, 1989).
Nakamura et al., "Purification and Characterization of a Growth Factor from Rat Platelets for Mature Parenchymal Hepatocytes in Primary Cultures" Proc. Natl. Acad. Sci, USA 83:6489-6493 (1986).
Nakamura et al., "Purification and Subunit Structure of Hepatocyte Growth Factor from Rat Platelets" FEBS Letters 224(2):311-316 (Nov. 1987).
Ogura et al., "Molecular Mechanism for the Formation of the High-Affinity Complex of Interleukin 2 and its Receptor" Mol. Biol. Med. 5:123-138 (1988).
Okajima et al., "Primary Structure of Rat Hepatocyte Growth Factor and Induction of Its mRNA During Liver Regeneration Following Hepatic Injury" European Journal of Biochemistry 193:375-381 (1990).
Pandit et al., "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor" Science 258:1358-1362 (1992).
Rubin et al., "A Broad-Spectrum Human Lung Fibroblast-Derived Mitogen is a Variant of Hepatocyte Growth Factor" Proc. Natl. Acad Sci, USA 88:415-419 (1991).
Seki et al., "Isolation and Expression of cDNA for Different Forms of Hepatocyte Growth Factor from Human Leukocyte" Biochem. and Biophys. Res. Commun. 172(1):321-327 (Oct. 15, 1990).
Tashiro et al., "Deduced Primary Structure of Rat Hepatocyte Growth Factor and Expression of the mRNA in Rat Tissues" Proc. Natl. Acad. Sci. USA 87:3200-3204 (1990).
Ullrich and Schlessinger, "Signal Transduction by Receptors with Tyrosine Kinase Activity" Cell 61:203-212 (Apr. 1990).
Yarden et al., "Growth Factor Receptor Tyrosine Kinases" Ann. Rev. Biochem. 57:443-478 (1988).
Chan et al. Science 254 (1991) 1382-1385.
Matsumoto et al. Biochem and Biophys. Res. Comm. 181(1991) 691-699.

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