Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1988-03-18
1989-02-28
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 43, 536 24, A61K 3140
Patent
active
048086134
ABSTRACT:
There are disclosed analogs of the antitumor agent, rebaccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.
REFERENCES:
patent: 4487925 (1984-12-01), Nettleton et al.
patent: 4552842 (1985-11-01), Nettleton et al.
Kaneko et al., Tetrahedron Letters, vol. 26(34), pp. 4015-4018, 1985.
Crom et al, Organic Chemistry, 2nd Edition, McGraw-Hill Book Co., N.Y., 1964.
Nettleton et al., Tetrahedron Letters, vol. 26(34), pp. 4011-4014, 1985.
Kaneko Takushi
Utzig Jacob J.
Wong Henry S.
Bristol-Myers Company
Crane L. Eric
Griffin Ronald W.
Morse David M.
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