Rebeccamycin derivative containing pharmaceutical composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 43, 536 24, A61K 3140

Patent

active

048086134

ABSTRACT:
There are disclosed analogs of the antitumor agent, rebaccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.

REFERENCES:
patent: 4487925 (1984-12-01), Nettleton et al.
patent: 4552842 (1985-11-01), Nettleton et al.
Kaneko et al., Tetrahedron Letters, vol. 26(34), pp. 4015-4018, 1985.
Crom et al, Organic Chemistry, 2nd Edition, McGraw-Hill Book Co., N.Y., 1964.
Nettleton et al., Tetrahedron Letters, vol. 26(34), pp. 4011-4014, 1985.

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