Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
1998-10-27
2001-10-30
Lateef, Marvin M. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S439000, C600S586000, C607S100000, C367S007000
Reexamination Certificate
active
06309352
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of imaging, thermotherapy, and cryotherapy. More specifically, the present invention relates to a method and system utilizing optoacoustic imaging to monitor, in real time, tissue properties during therapeutic or surgical treatment.
2. Description of the Related Art
Various types of therapeutic agents (radiation, heating, cooling, drugs, surgical tools) are being used for treatment. It is necessary to monitor tissue physical properties during treatment to provide selective damage to diseased tissues. This will result in better outcome of any treatment procedure. It is highly desirable to develop an imaging technique which will be capable of monitoring tissue physical parameters in real time during treatment. Such an imaging technique will provide feed-back information which will be used to optimize treatment procedure. All conventional imaging techniques have limitations such as low contrast (ultrasound and X-ray imaging), high cost (MRI, PET), poor resolution (PET). Some of them are not capable of providing imaging information in real time. Due to these limitations, these conventional techniques are not being widely applied for monitoring tissue physical properties in real time during treatment.
It has been demonstrated that thermally treated tissues possess optical properties that are significantly different from normal untreated tissues. For example, the optical properties of coagulated and normal tissues are different. It was also demonstrated that different regimes of coagulation may yield different end values of tissue optical properties. A hemorrhage ring was observed at the boundary between coagulated and normal tissue in vivo.
The prior art is deficient in the lack of effective means of monitoring of tissue parameters in real time during therapeutic or surgical treatment. The present invention fulfills this long-standing need and desire in the art.
SUMMARY OF THE INVENTION
The present invention is directed to a method/system of real-time optoacoustic monitoring of tissue physical properties with the purpose of providing selective damage of diseased tissues and assuring minimal damage to surrounding normal tissues during therapy.
In one embodiment of the present invention, there is provided a method of monitoring tissue properties in real time during treatment using a laser optoacoustic imaging system, comprising the steps of administering a treatment agent to the tissue and applying the optoacoustic imaging system to the treated tissue. Preferably, the tissue can be selected from various organs with tumors or other lesions, and the tissue properties are referred to physical dimension, optical absorption, optical scattering, optical attenuation coefficient, temperature, thermal expansion coefficient, speed of sound or heat capacity. Representative treatment agents include optical radiation, electromagnetic radiation, ultrasonic radiation, electrical current, heating, cooling, a drug or a surgical tool.
In another embodiment of the present invention, there is provided a system of monitoring tissue properties in real time during treatment, comprising a system for administering a treatment agent to the tissue; an optoacoustic imaging system for providing images; an exogenous molecular probe for reflecting the treatment; and a feed-back electronic system for adjusting parameters of the treatment agent.
Other and further aspects, features, and advantages of the present invention will be apparent from the following description of the presently preferred embodiments of the invention given for the purpose of disclosure.
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Esenaliev Rinat O.
Karabutov Alexander A.
Motamedi Massoud
Oraevsky Alexander A.
Baman & Rogalskyj, LLP
Board of Regents , The University of Texas System
Lateef Marvin M.
Shaw Shawna J
LandOfFree
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