Real time measurement of cellular responses

Details Real time measurement of cellular responses Real time measurement of cellular responses

Filed on

2005-06-14

Date issued

2005-06-14

Examiner

Ketter, James (Department: 1636)

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Measuring or testing process involving enzymes or...

SubSubClass

Involving nucleic acid

Other Related Categories

C435S455000, C435S366000

Type

Reexamination Certificate

Status

active

Patent number

06905831

Description

ABSTRACT:
Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally-aided observation. These observations may be made, if desired, in real time. In addition, rates of proliferation and drug sensitivities can be determined in vitro in real time by the use of cells modified to express a single fluorescent protein and observing fluorescence intensity as a function of time.

REFERENCES:
Gerdes and Kaether, FEBS Letters 389:44-47 (1996).
Kanda et al., Curr. Biol. 8:377-385 (1998).
Kawakami et al., Immunology Lett 70:165-171 (1999).
Yang et al., Clin. Exp. Metastasis 17:417-422 (1999).
Yang et al., Proc. Natl. Acad. Sci. USA 97:1206-1211 (2000).
Yang et al., Proc. Natl. Acad. Sci. USA 97:12278-12282 (2000).
Yang et al., Proc. Natl. Acad. Sci. USA 98:2616-2621 (2001).
Yang et al., Proc. Natl. Acad. Sci. USA 99:3824-3829 (2002).
Zhao et al., Proc. Natl. Acad. Sci. 98:9814-9818 (2001).
International Search Report, mailed on Feb. 11, 2004, for PCT/US03/22308, 4 pages.
Terjung et al., Clin. Exp. Immunol. (2001) 126:37-46.
Zhai et al., J. Biol. Chem. (2001) 276(44):41318-41324.
Zhang et al., J. Cell Sci. (2001) 114(24):4485-4498.

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