Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-12-19
1999-04-06
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
422 55, 422 56, 422 58, 422 60, 422 8205, 422 8209, 422 99, 435 71, 435 78, 435 792, 435 793, 435 795, 4352872, 4352877, 4352878, 435961, 436518, 436538, 436541, 436805, G01N 33533
Patent
active
058916490
ABSTRACT:
The present invention is an apparatus and a method of detecting a chemical released by perspiration, typically through sweat and broadcasting the detection to a receiver. The chemical may be a drug of abuse. The device which is attached to the skin of a subject contains labeled antibodies or label containing microspheres attached to antibodies. The labeled antibodies are bound to solid phase drug via antigen-antibody interaction. These labeled antibodies are displaced from the solid phase support to which they are bound by free drug molecules in the perspiration. These labeled antibodies then migrate through a spacer layer and are trapped by a layer containing a suitable selective binding material. The label is illuminated or excited by a light source and detected by a photodetector. The signal can be recorded, or transmitted to a remote radio monitor.
REFERENCES:
patent: 5340748 (1994-08-01), Baugher et al.
patent: 5369007 (1994-11-01), Kidwell
patent: 5520787 (1996-05-01), Hanagan et al.
Kern Roger G.
Kidwell David A.
Mintz Frederick W.
Richards Gil F.
California Institute of Technology
Chin Christopher L.
Nguyen Bao-Thuy L.
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