Reaginic test for syphilis

Details Reaginic test for syphilis Reaginic test for syphilis

1985-12-03

1988-04-19

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving diffusion or migration of antigen or antibody

Through a gel

436518, 436532, 436533, 436534, 436808, 436811, 435 5, 435181, 435810, G01N 33571, G01N 33543, G01N 33549

Patent

active

047389320

ABSTRACT:
A reaginic agglutination test for syphilis-associated antibodies is disclosed. The test uses an antigen reagent that comprises a buffered aqueous suspension of cardiolipin antigen ionically coupled to latex particles via a polypeptide bridge. Positive sera react with the antigen reagent and yield an agglutination pattern characterized by medium to large aggregates. Negative sera yield no agglutinated particles.

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Manual of Tests for Syphilis, U.S. Dept. of Health, Education, and Welfare (1969), pp. 23-26, 33-42.
Larsen, S. A., Current Status of Laboratory Tests for Syphilis (1983), pp. 162-170.
Pettit, D. E., et al., Journal of Clin. Microbiol. (1983), 18:1141-1145.

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