Reagents used in the radioimmunoassay of digoxin

Details Reagents used in the radioimmunoassay of digoxin Reagents used in the radioimmunoassay of digoxin

1975-01-14

1977-05-03

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

536 7, 424182, A61K 4300

Patent

active

040215350

ABSTRACT:
The derivatives of digoxin useful in the radioimmunoassay of digoxin having the following formulae: ##STR1## where R is a carboxylic acid ester. These derivatives are formed by the following process: (1) reacting the carboxylic acid in the presence of trifluoroacetic anhydride with a solution of digoxin in an inert, nonaqueous solvent medium, (2) adding water so as to form the above derivatives, (3) purifying the above derivatives from other constituents of the reaction mixture and (4) radio-labeling these derivatives for use as a labeled hapten in the radioimmunoassay of digoxin.
The preferred carboxylic acids are imidazoleacetic acid and p-hydroxyphenylpropionic acid. The preferred radioactive isotope is .sup.125 I.

REFERENCES:
patent: 3471470 (1969-10-01), Heider et al.
patent: 3753975 (1973-08-01), Kaiser et al.
patent: 3804825 (1974-04-01), Losel et al.
British Medical Bulletin, Hunter, W. M., "Prep. and Assessment of Radioactive Tracers," vol. 30, No. 1, 1974, pp. 18-23.
".sup.125 I and .sup.3 H Radioimmunoassay Kits For Digoxin and Digitoxin," Schwart/Mann Flyer, Aug. 1973.
Fieser, et al., "Reagents for Org. Syn." Wiley and Sons, Inc., 1967, p. 1223.

Affiliated with

Also associated with

Rating

Reagents used in the radioimmunoassay of digoxin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reagents used in the radioimmunoassay of digoxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagents used in the radioimmunoassay of digoxin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-346067