Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1986-08-27
1990-05-29
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 7, 4357021, 4351722, 435810, 43524027, 436536, 436537, 436542, 436548, 436 64, 436 94, 436804, 436808, 436809, 436813, 436815, 436822, 935104, 935110, 530387, G01N 33577, G01N 33574
Patent
active
049295446
ABSTRACT:
Human cancer is diagnosed/monitored by measuring the levels of N-[9-(.beta.-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine (t.sup.6 A), in a physiological fluid specimen of a subject by a quantitative immunoassay that employs a monoclonal anti-t.sup.6 A antibody and comparing that level to the level of t.sup.6 A that occurs in corresponding physiological fluid of normal subjects to determine whether the former is substantially elevated over the latter or by comparing that level to the level of t.sup.6 A present in specimens taken from the subject at different times.
REFERENCES:
patent: 4665018 (1987-05-01), Vold
Vold, B. S. et al., "Use of a Monoclonal Antibody to Detect Elevated Levels of a Modified Nucleoside, N-[9-(B-D-Ribo-furanosyl)purin-6-ylcarbamoyl]-L-threonine, in the Urine of Breast Cancer Patients," Canc. Res. 46:3164-3167, Jun. 1986.
Cheney Kay E.
Moskowitz Margaret
SRI - International
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