Reagents, methods and kits for detecting trichloroethylene and p

Details Reagents, methods and kits for detecting trichloroethylene and p Reagents, methods and kits for detecting trichloroethylene and p

1996-05-31

1999-11-30

Caputa, Anthony C.

Chemistry: analytical and immunological testing

Hydrocarbon

436142, 436145, 436501, 436536, G01N 3300, G01N 33566

Patent

active

059941456

ABSTRACT:
Reagents, immunoassay methods, and kits for detecting the presence or amount of trichloroethylene or perchloroethylene in a sample. Reagents include antibodies, immunogens for preparing antibodies, and assay conjugates. The immunogens elicit high affinity antibodies to trichloroethylene. The antibodies have minimal crossreactivity to other halogenated and aromatic hydrocarbons. The assay conjugates provide for sufficient binding of the antibody to the conjugate with maximum inhibition of that binding by free trichloroethylene and perchloroethylene in the sample. The reagents are useful in immunoassays to detect trichloroethylene and perchloroethylene, especially in environmental samples. Kits contain antibodies specific for trichloroethylene and perchloroethylene and assay conjugates.

REFERENCES:
patent: 5145790 (1992-09-01), Mattingly et al.
patent: 5273909 (1993-12-01), Piasio
Kearney et al., "A New Mouse Myeloma Cell Line That Has Lost Immunoglobulin Expression But Permits The Construction of Antibody-Secreting Hybrid Cell Lines," J. Immunology, vol. 123, pp. 1548-1550 (Oct. 1979).
Hudak et al., Abstract of "Validation of An Immunoassay Field Screen for Trichloroethylene (TCE)," paper presented by Strategic Diagnostics, Inc. at International Symposium on Field Screening Methods for Hazardous Wastes and Toxic Chemicals, Feb. 22-24, 1995, Las Vegas, NV.

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