Reagents for use in binding assays to determine diphenylhydantoi

Details Reagents for use in binding assays to determine diphenylhydantoi Reagents for use in binding assays to determine diphenylhydantoi

1978-04-25

1980-01-08

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 53, 548314, 260112R, 424 12, C07H 1700, C07H 1704

Patent

active

041828569

ABSTRACT:
Reagents for use in binding assays, particularly immunoassays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and o-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and o-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and o-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

REFERENCES:
patent: 3905871 (1975-09-01), Rubenstein et al.
patent: 4045556 (1977-08-01), Schwertner et al.
patent: 4060603 (1977-11-01), Morgan et al.

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