Reagents for use as calibrators and controls

Details Reagents for use as calibrators and controls Reagents for use as calibrators and controls

1996-01-23

2000-01-18

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, 435 722, 435 731, 435 732, 435 734, 436548, G01N 33569, G01N 33577

Patent

active

060156627

ABSTRACT:
The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.

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