Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-26
2010-06-22
Lewis, Patrick T (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025310, C536S025320, C536S025330, C536S025340
Reexamination Certificate
active
07741471
ABSTRACT:
The present invention provides the combination of the O-2 diphenylcarbamoyl (“DPC”) and N-6 dimethylaminomethylidene (“DMF”) protecting groups for isoguanosine nucleosides that can be utilized in oligonucleotide synthesis.
REFERENCES:
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4973679 (1990-11-01), Caruthers et al.
patent: 5256549 (1993-10-01), Urdea et al.
patent: 5430138 (1995-07-01), Urdea et al.
patent: 6147199 (2000-11-01), Seela et al.
patent: 6498241 (2002-12-01), Seela et al.
Roberts et al. Tetrahedron Letters (1995), vol. 36, pp. 3601-3604.
Seela, Frank et al., “Oligonucleotides Containing Consecutive 2′-Deoxyisoguanosine Residues: Synthesis, Duplexes with Parallel Chain Orientation, and Aggregation,”Helvetica Chimica Acta,1997, vol. 80, pp. 73-85.
Seela, Frank et al., “Synthesis of Phosphonates and Oligodeoxyribonucleotides Derived from 2′-Deoxyisoguanosine and 2′-Deoxy-2-haloadenosines,”Helvetica Chimica Acta,1992, vol. 75, pp. 2298-2306.
Jurczyk, Simona C. et al., “Synthesis of Oligonucleotides Containing 2′-Deoxyisoguanosine and 2′-Deoxy-5-methylisocytidine Using Phosphoramidite Chemistry,”Helvetica Chimica Acta,1998, vol. 81, pp. 793-811.
Vu, Huynh et al., “Fast Oligonucleotide Deprotection Phosphoramidite Chemistry for DNA Synthesis,”Tetrahedron Letters,1990, vol. 31(50), pp. 7269-7272.
Roberts, Christopher et al., “Theoretical and Experimental Study of Isoguanine and Isocytosine: Base Pairing in an Expanded Genetic System,”J. Am. Chem. Soc.,1997, vol. 119, pp. 4640-4649.
Seela, Frank et al., “Quadruplex and Pentaplex Self-Assemblies of Oligonucleotides Containing Short Runs of 8-Aza-7-deaza-2′-deoxyisoguanosine or 2′-Deoxyisoguanosine,”Bioconjugate Chem.,2001, vol. 12, pp. 1043-1050.
McBride, Lincoln J. et al., “Amidine Protecting Groups for Oligonucleotide Synthesis,”J. Am. Chem. Soc.,1986, vol. 108, pp. 2040-2048.
Horn, Thomas et al., “Hybridization Properties of the 5-Methyl-Isocytidine/Isoguanosine Base Pair in Synthetic Oligodeoxynucleotides,”Tetrahedron Letters,1995, vol. 36(12), pp. 2033-2036.
Li, Hong et al., “Fluorescence quenching of parallel-stranded DNA bound ethidium bromide: the effect of 7-deaza-2′-deoxyisoguanosine and 7-halogenated derivatives,”Bioorganic&Medicinal Chemistry Letters,2004, vol. 24, pp. 6031-6034.
Seela, Frank et al., “Parallel-stranded oligonucleotide duplexes containing 5-methylisocytosine-guanine and isoguanine-cytosine base pairs,”Tetrahedron Letters,1999, vol. 55, pp. 9481-9500.
Rice, Kevin P. et al., “RecA Protein Promotes Strand Exchange with DNA Substrates Containing Isoguanine and 5-Methyl Isocytosine,”Biochemistry,2000, vol. 39, pp. 10177-10188.
International Search Report dated Jun. 16, 2006.
Beaucage, Serge et al., “Deoxynucleotide phosphoramidites—a new class of key intermediates for deoxypolynucleotide synthesis,”Tetrahedron Letters,1981, vol. 22(20), pp. 1859-1862.
Supplemental European Search Report dated May 26, 2008 for EP 05760503.2.
Examination Report issued in European Appln. No. 05760503.2 dated Nov. 6, 2009.
Prudent James R.
Sherrill Christopher B.
EraGen Biosciences, Inc.
Foley & Lardner LLP
Lewis Patrick T
LandOfFree
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