Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-03-15
2011-03-15
Haq, Shafiqul (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S015000, C435S070210, C435S452000, C435S194000, C435S331000, C435S338000, C435S975000, C436S518000, C436S536000, C436S547000, C436S548000, C530S387100, C530S388260, C530S389100, C530S391100, C530S391300
Reexamination Certificate
active
07906297
ABSTRACT:
The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA peptides, that selectively bind to and/or detect ATR only when phosphorylated at one or more of these respective sites, but do not bind to ATR when not phosphorylated at these respective sites. Also provided are methods for determining the phosphorylation of ATR kinase in a biological sample, by using a detectable reagent that binds to ATR only when phosphorylated at Ser428 and/or Ser2317. Kits comprising the ATR (Ser428, Ser2317)-specific reagents of the invention are also provided.
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Internet citation: http://las.perkinelmer.com/Catalog/ProductInfoPage.htm?ProductID=AD0186 and http://las.perkinelmer.com/Catalog/COASearch.htm?CatalogNumber=AD0186, 2009.
Livingstone Mark
Polakiewicz Robert
Ruan Hong
Cell Signaling Technology, Inc.
Grun James L
Haq Shafiqul
Wilker Nancy Chiu
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