Reagents for screening tests and bioassay of von Willebrand's fa

Chemistry: physical processes – Physical processes – Crystallization

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252408, 424 3, 424 98, G01N 3316, C09K 300, A61K 3538

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active

041451856

ABSTRACT:
Screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in human and animal blood plasma are effected using a reagent of blood platelets and snake venom having a positive platelet aggregating cofactor effect. The reagent and tests may also suitably employ dried blood platelets. The reagent may comprise dried platelets and either ristocetin or active snake venom as the platelet aggregating cofactor.

REFERENCES:
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patent: 3715427 (1973-02-01), Hirata
patent: 3761586 (1973-09-01), Matsumoto et al.
patent: 3819605 (1974-06-01), Holleman et al.
patent: 3869548 (1975-03-01), Dabis
patent: 3987159 (1976-10-01), Spona et al.
M. C. Boffa et al., Biochimica et Biophysica Acta, vol. 354, No. 2, pp. 275-290 (Jul. 1974).
J. P. Allain et al., J. Lab. Clin. Med., vol. 85, No. 2, pp. 318-328 (Feb. 1975).
N. MacKay et al., Effects of the Venom of the Rhinoceros Horned Viper (Bitis nasicornis) on Blood Coagulation Platelet Aggregation, and Fibrinolysis, J. Clin. Path., vol. 23, No. 9, pp. 789-796 (1970).

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