Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-10-28
1983-11-01
Sneed, Helen M. S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260196, 260201, C07C10708
Patent
active
044129513
ABSTRACT:
A reagent for measuring a lipase activity comprised of a higher fatty acid ester having the general formula ##STR1## wherein R.sup.1 is a straight chain alkyl group; R.sup.2 is hydrogen or a halogen atom; R.sup.3 and R.sup.4 are independently a nitro group, an alkylsulfonyl group, a substituted alkylsulfonyl group or a trifluoromethyl group; G is an --SO.sub.3 M group or a group having at least one --SO.sub.3 M where M represents sodium or potassium, or, when R.sup.4 has a sulfonic acid group, may be a hydrogen atom; and Q is hydrogen, a halogen atom, an alkyl group, an alkoxy-substituted alkyl group, an alkoxy group, an alkoxy-substituted alkoxy group, a sulfonamido group, a sulfamoyl group, a carbonamido group, a carbamoyl group, or an alkylsulfonyl group. The reagent is capable of releasing a dye on enzymatic hydrolysis by the action of lipase. Because of the released dye has a light absorption zone within the longer wavelength region, it is not substantially disturbed by colored matter contained within blood making it possible to obtain excellent operability and reproducibility in the measurement of lipase activity within blood.
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Fujita Shinsaku
Inagaki Yoshio
Okazaki Masaki
Fuji Photo Film Co. , Ltd.
Sneed Helen M. S.
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