Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1997-06-12
2000-05-16
Ceperley, Mary E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530404, 530807, C07K 1702, C07D45706
Patent
active
060639083
ABSTRACT:
The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for the detection of LSD and nor-LSD. In the present invention the LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. Derivatives have also been synthesized out of the piperidine nitrogen of the LSD nucleus. The resulting haptens can then be further modified at these functionalized positions for linking to appropriate antigenic or labelling groups to provide reagents for LSD immunoassays having excellent sensitivity and selectivity for both LSD and nor-LSD.
REFERENCES:
patent: 4199559 (1980-04-01), Ullman et al.
patent: 4375414 (1983-03-01), Strahilevitz
patent: 4754037 (1988-06-01), Gervais
patent: 5144030 (1992-09-01), Wang et al.
patent: 5237057 (1993-08-01), Buechler et al.
patent: 5843682 (1998-12-01), Sigler et al.
A.J. McNally et al., J. Analytical Toxicology, vol. 20, pp. 404-408, Oct. 1996.
E. W. Voss, Jr. et al., Psychopharmacologia (Berl.) vol. 26, pp. 140-145, 1972.
A. Castro et al., Research Communications in Chemical Pathology and pharmacology, vol. 6, No. 3, pp. 879-886, Nov. 1973.
A.A. Luderer et al., Bull. New Jersey Acad. Sci., vol. 19, No. 1, pp. 8-10, 1974.
B. Erlanger, Methods in Enzymology, vol. 70, pp. 85-104, 1980.
I. Maggio (editor), Enzyme-immunoassay, Chemical Aspects of Enzyme-immunoassay, Chapter 4, CRC Press, Inc., 1980.
Chemical Abstracts, abstract No. 78869m, 80(15):60 (1974).
Ziegler et al., Biochimica Biophysica Acta., 773;11-12 (1984).
Marzoni et al., Synthesis-Stuttgart, 7:651 (1987).
Ratcliffe, Clin. Chem., 23(2):169-174 (1977).
Taunton-Rigby, Science, 181:165-166 (1973).
Van Vunakis, Proc. Nat. Acad. Sci., 68(7):1483-1487 (1971).
A. Hubbard et al., Anal. Proc., 20:606 (1983).
Salamone Salvatore Joseph
Vitone Stephen S.
Wu Robert Sundoro
Ceperley Mary E.
Roche Diagnostics Corporation
LandOfFree
Reagents for lysergic acid diethylamide immunoassay does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reagents for lysergic acid diethylamide immunoassay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagents for lysergic acid diethylamide immunoassay will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-259897