Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2005-11-22
2005-11-22
Berch, Mark L. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C435S006120, C435S040500, C544S287000, C544S092000, C548S269400, C548S224000, C548S180000
Reexamination Certificate
active
06967251
ABSTRACT:
Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula:wherein Q is carbonyl, thiocarbonyl, or sulfonyl, and R5is -L-Z; L is arylene, or a C1-6perfluoroalkylene, or a single covalent bond; Z is a carbonyl hydrazide, hydrazide, sulfonyl hydrazide, or a thiocarbonyl hydrazide; R11-R14are independently H, C1-6alkyl, C1-6alkoxy, C1-6perfluoroalkyl, C1-6alklyamino, di(C2-12alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, or sulfo; and R21-R24are independently H, C1-6alkyl, C1-6alkoxy, C1-6perfluoroalkyl, C1-6alklyamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, sulfo, or -L-Z. The method of treating a sample with the derivativization reagents is described. The reagents are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.
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Diwu Zhenjun
Haugland Richard P.
Patton Wayne F.
Steinberg Thomas H.
Anderson Koren J.
Berch Mark L.
Molecular Probes, Inc.
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