Reagents for isotropic size enhancement of a peptide, protein, n

Details Reagents for isotropic size enhancement of a peptide, protein, n Reagents for isotropic size enhancement of a peptide, protein, n

1997-07-21

2000-01-25

Fonda, Kathleen K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 111, 536 41, 536 172, 536 187, 536 20, 536 21, 536 51, 536 53, 536112, 5361231, 514 23, 514 25, 514 42, 514 54, 514 55, 514 56, 514 59, C07H 1900, A61K 3170

Patent

active

060180358

ABSTRACT:
Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.

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Hascall et al., Immunology of Chondroitin/Dermatan Sulfate, in Glycoimmunology, Alavi, A. and Axford, A. S. eds., Plenum Press, New York, pp. 205-216 (1995)-published sufficiently before filing date such that the month is not an issue. month not available.
Connective Tissue Proteoglycans, in The Biochemistry of Glycoproteins and Proteogycans, W. J. Lennarz ed., Plenum Press, New York, pp. 286-314 (1980). month not available

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