Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2006-01-24
2006-01-24
Marschel, Ardin H. (Department: 1631)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C536S001110, C536S018700, C536S123100, C514S002600, C514S04400A, C514S023000
Reexamination Certificate
active
06989434
ABSTRACT:
The present invention provides certain cationic lipids containing stigmasterol, ergosterol and cholic acid groups. Compounds of the invention are useful, either alone or in combination with other lipid aggregate-forming components (e.g., DOPE, DOSPA, DOTMA or cholesterol) for formulation into liposomes or other lipid aggregates. Such aggregates are cationic, and able to form stable complexes with anionic macromolecules, such as nucleic acids. The cationic lipids of the invention are useful in methods of transfecting cells, particularly to introduce nucleic acids into cells. The invention also related to kits for the preparation of lipid aggregates and to lipid aggregates and compositions for transfection of cells.
REFERENCES:
patent: 2901461 (1959-08-01), Auerbach et al.
patent: 3152188 (1964-10-01), Kirkpatrick et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5165925 (1992-11-01), Leong
patent: 5171678 (1992-12-01), Behr et al.
patent: 5208036 (1993-05-01), Eppstein et al.
patent: 5279833 (1994-01-01), Rose
patent: 5283185 (1994-02-01), Epand et al.
patent: 5334761 (1994-08-01), Gebeyehu et al.
patent: 5455335 (1995-10-01), Kahne et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5545412 (1996-08-01), Eppstein et al.
patent: 5550289 (1996-08-01), Eppstein et al.
patent: 5578475 (1996-11-01), Jessee
patent: 5583198 (1996-12-01), Whittaker
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5595897 (1997-01-01), Midoux et al.
patent: 5627159 (1997-05-01), Shih et al.
patent: 5635487 (1997-06-01), Wolff et al.
patent: 5650096 (1997-07-01), Harris et al.
patent: 5674908 (1997-10-01), Haces et al.
patent: 5693509 (1997-12-01), Cotten et al.
patent: 5703055 (1997-12-01), Felgner et al.
patent: 5719131 (1998-02-01), Harris et al.
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5744335 (1998-04-01), Wolff et al.
patent: 5753613 (1998-05-01), Ansell et al.
patent: 5780053 (1998-07-01), Ashley et al.
patent: 5783565 (1998-07-01), Lee et al.
patent: 5785992 (1998-07-01), Ansell et al.
patent: 5795587 (1998-08-01), Gao et al.
patent: 5827703 (1998-10-01), Debs et al.
patent: 5830430 (1998-11-01), Unger et al.
patent: 5830878 (1998-11-01), Gorman et al.
patent: 5834439 (1998-11-01), Haces et al.
patent: 5840710 (1998-11-01), Lee et al.
patent: 5854224 (1998-12-01), Lockett et al.
patent: 5861397 (1999-01-01), Wheeler
patent: 5869606 (1999-02-01), Whittaker
patent: 5906922 (1999-05-01), Whittaker et al.
patent: 5908635 (1999-06-01), Thierry
patent: 5908777 (1999-06-01), Lee et al.
patent: 5935936 (1999-08-01), Fasbender et al.
patent: 5948767 (1999-09-01), Scheule et al.
patent: 5948925 (1999-09-01), Keynes et al.
patent: 6020202 (2000-02-01), Jessee
patent: 6051429 (2000-04-01), Hawley-Nelson et al.
patent: 6086913 (2000-07-01), Tam et al.
patent: 6110662 (2000-08-01), Foung et al.
patent: 6110916 (2000-08-01), Haces et al.
patent: 6214804 (2001-04-01), Felgner et al.
patent: 6376248 (2002-04-01), Hawley-Nelson et al.
patent: 6387395 (2002-05-01), Eppstein et al.
patent: 6399663 (2002-06-01), Haces et al.
patent: 2002/0077305 (2002-06-01), Jessee et al.
patent: 2002/0086849 (2002-07-01), Gebeyehu et al.
patent: 2002/0156049 (2002-10-01), Haces et al.
patent: 2003/0069173 (2003-04-01), Hawley-Nelson et al.
patent: 0 394 111 (1990-10-01), None
patent: 0 846 680 (1998-06-01), None
patent: 1567214 (1969-05-01), None
patent: WO 90/11092 (1990-10-01), None
patent: 91/15501 (1991-10-01), None
patent: 91/16024 (1991-10-01), None
patent: WO 91/17424 (1991-11-01), None
patent: WO 93/03709 (1993-03-01), None
patent: WO 93/05162 (1993-03-01), None
patent: WO 93/14778 (1993-08-01), None
patent: WO 94/27435 (1994-12-01), None
patent: WO 95/02698 (1995-01-01), None
patent: WO 95/17373 (1995-06-01), None
patent: WO 96/40961 (1996-12-01), None
patent: WO 97/42819 (1997-11-01), None
patent: WO 98/02190 (1998-01-01), None
patent: WO 98/14439 (1998-04-01), None
patent: WO 98/19709 (1998-05-01), None
patent: WO 98/29541 (1998-07-01), None
patent: WO 98/40502 (1998-09-01), None
patent: WO 99/02190 (1999-01-01), None
patent: WO 99/29712 (1999-06-01), None
patent: WO 00/27795 (2000-05-01), None
patent: WO 00/58488 (2000-10-01), None
patent: WO 02/34879 (2002-05-01), None
Sigma Chemical Catalog, Sigma Chemical Company, St Louis Missouri, pp. 868 and 1649-1657, 1990.
Sigma Chemical Catalog, Sigma Chemical Company, P.O. Box 14508, St. Louis, Missouri, p. 1066, 1990.
Wood et al., Hypertension, vol. 7, No. 5, pp. 797-803, 1985.
New Riverside University Dictionary Published by the Riverside Publishing Company, Houghton Mifflin Company, One Beacon Street, Boston, Massachusetts 02108) (1984), p. 1324.
Biochemistry, by Lehninger Published by Worth Publishers, Inc., 70 Fifth Avenue, New York, New York, 10011 (1970) pp. 69-71, 98, 99, 227-229, and 233.
Christensen et al., Biochemical and Biophysical Research Communications, vol. 155, No. 3, pp. 1278-1283 (1988).
Chang et al., Biochemistry, vol. 14, No. 3, pp. 468-477 (1975).
Barthel, F. et al. (1993), “Gene Transfer Optimization with Lipospermine-Coated DNA,” DNA and Cell Biology 12(6):553-560.
Behr, J.-P. et al. (1989), “Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA,” Proc. natl. Acad. Sci. USA 86:6982-6986.
Duzgunes, N. et al. (1989), “Fusion of Liposomes containing a Novel Cationic Lipid, N-[2,3-(Dioleyloxy)propyl]-N,N,N-trimethylammonium: Induction by Multivalent Anions and Asymmetric Fusion with Acidic Phospholipid Vesicles,” Biochemistry 28:9179-9184.
Felgner, P.L. et al. (1987), “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure,” Proc. Natl. Acad. Sci. USA 84:7413-7417.
Gao, X. et al. (1991), “A Novel Cationic Liposome Reagent for Efficient Transfection of Mammalian Cells,” Biochim. Biophys. Res. Comm. 179:280-285.
Loeffler, J.-P. et al. (1993), “Gene Transfer into Primary and Established Mammalian Cell Lines with Lipopolyamine-Coated DNA,” Methods Enzymol. 217:599-618.
Zhou, X. et al. (1991), “Lipophilic polylysines mediate efficient DNA transfection in mammalian cells,” Biochim. Biophys. Acta 1065:8-14.
Sigma Chemical Catalog,(1990) Published by the Sigma Chemical Co., St. Louis, MO, pp. 560, 670 and 671.
Felgner et al. (1993) Keystone Symposium on Genetic Targeted Research and Therapeutics: Antisense and Gene Therapy, Keystone, CO; J. Cell. Biochem. Suppl. 0(17 Part E), p. 206, S306.
Lehninger (1970) Biochemistry (Published by Worth Publishers, Inc., New York, NY, pp. 69-71.
Sigma Chemical Catalog (1990) Published by the Sigma Chemical Co., St. Louis, MO, p. 1107.
Budker et al. (1997) “Protein/Amphipathic Polyamine Complexes Enable Highly Efficient Transfection with Minimal Toxicity”BioTechniques23:139-147.
Behr, J-P. (Sep. 1994), “Gene Transfer with Synthetic Cationic Amphiphiles: Prospects for Gene Therapy,” Bioconjug. Chem. 5:382-389.
Bottger, M. et al. (1988), “Condensation of vector DNA by the chromosomal protein HMGI results in efficient transfection,” Biochim. Biophys. Acta 950:221-228.
Cotten, M. and Wagner, E. (Dec. 1993), “Non-viral approaches to gene therapy,” Curr. Opin. Biotechnol. 4:705-710.
Giles, R.V. (2000), “Antisense oligonucleotide technology: From EST to therapeutics,” Curr. Opin. Mol. Therap. 2:238-252.
Henkel and Cie. G.m.b.H. (Apr. 1970), abstract no. 68522p, “Low-foaming detergents containing bisquaternary compounds,” Chem. Abst. 72(14):116.
Kaneda, Y. et al. (1989), “Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver,” Science 243:375-378.
Murphy, A.L. (Jan. 1999), “Catch VP22: the hitch-hiker's ride to gene therapy?” Gene Therapy 6:4-5.
Neckers, L.M. (May 1993), “Cellular Internalization of Oligodeoxynuc
Gebeyehu Gulilat
Jessee Joel A.
Greenlee Winner and Sullivan P.C.
Invitrogen Corporation
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