Reagents for generating a polyclonal hydrolytic antibody respons

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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530409, 530362, 530363, 530380, 546 23, 4351885, C07K 1702, C07K 1646

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054630282

ABSTRACT:
This invention provides a compound comprising a methyl ecgonine group chemically attached to a phenylphosphonic group which is an analog to an intermediate of the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto.

REFERENCES:
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4888281 (1989-12-01), Schochetman et al.
patent: 4963355 (1990-10-01), Kim et al.
patent: 5030717 (1991-07-01), Tramontano et al.
patent: 5037750 (1991-11-01), Schochetman et al.
patent: 5187086 (1993-02-01), Janda
Kibbe et al (1977) Pharmacological Research Communications 9(4):367-374.
Landry et al (1993) Science 259:1899-1901.
Morell (1993) Science 259:1828.
Aldrich Catalog (1992) p. 468.
Fauci, A. S., (Feb. 1988) The Human Immunodeficiency Virus: Infectivity And Mechanisms of Pathogenesis, Science, 239:617-622 (Exhibit I).
Gatley, S. J., et al. (1990), Rapid Stereoselective Hydrolysis of (+)-Cocaine in Baboon Plasma prevents its uptake in the Brain: Implications for Behavioral Studies, J. Neurochem. 54:720-723, (Exhibit J).
F. H. Gawin and E. H. Ellinwood, Jr. "Cocaine and other stimulants: Actions, abuse and treatment", New Eng. J. Med. 1988, 318:1173-1182.
L. M. Lesko et al., "Iatrogenous cocaine psychosis", N. Eng. J. Med. 1982, 307:1153.
N. E. Goeders and J. E. Smith, "Cortical dopaminergic involvement in cocaine reinforcement", Science 1983, 221:773-775.
F. H. Gawin et al., "Desipramine facilitation of initial cocaine abstinence", Arch. Gen. Psychiatry 1989, 46:117-121.
F. H. Gawin et al., "Outpatient treatment of `crack` cocaine smoking with flupenthixol decanoate", Arch. Gen Psychiatry 1989, 46:322-325.
M. W. Fischman, et al., "Effects of desipramine maintenance on cocaine self-administration by humans", J. Pharm and Exper. Therapeu. 1990, 253:760-770.
K. F. Bonese et al., "Changes in heroin self-administration by a rhesus monkey after morphine immunization", Nature 1974, 252:708-710.
A. Tramontano et al., "Catalytic antibodies", Science 1986, 234:1566-1570.
S. J. Pollack et al., "Selective chemical analysis by an antibody", Science 1986, 234:1570-1573.
S. J. Benkovic, et al., "Catalysis of a stereospecific bimolecular amide synthesis by an antibody", Proc. Natl. Acad. Sci. USA 1988, 85:5355-5358.
D. Y. Jackson, et al., "An antibody-catalyzed claisen rearrangement", J. Am. Chem. Soc. 1988, 110:4841-4842.
S. J. Benkovic et al., "The enzymic nature of antibody ctaalysis: Development of multistep kinetic processing", Science 1990, 250:1135-1139.
K. D. Janda et al. "Induction of an antibody that catalyzes the hydrolysis of an amide bond", Science 1988, 241:1188-1191.
K. M. Shokat, et al., "A new strategy for the generation of catalytic antibodies", Nature 1989, 338:269-271.
B. L. Iverson and R. A. Lerner, "Sequence-specific peptide cleavage catalyzed by an antibody", Science 1989, 243:1184-1188.
T. Kitazume et al., "Antibody-catalyzed double stereoselection in fluorinated materials", J. Am. Chem. Soc. 1991, 113:8573-8575.
A. G. Cochran, et al., "Antibody-catalyzed biomolecular imine formation", J. Am. Chem. Soc. 1991, 113:6670-6672.
K. D. Janda, et al., "Catalytic antibodies with acyl-transfer capabilities: Mechanistic and kinetic investigations", J. Am. Chem. Soc 1991, 113:291-297.
A. Tramontano, et al., "Chemical reactivity at an antibody biding site elicited by mechanistic design of a synthetic antigen", Proc. Natl. Acad. Sci. 1986, 83:6736-6740.
K. D. Janda et al., "Catalytic antibodies with lipase activity and R or S substrate selectivity", Science 1989, 244:437-440.
A. Tramontano, et al., "Antibody catalysis approaching the activity of enzymes", J. Am. Chem. Soc. 1988, 110:2282-2286.
K. D. Janda et al., "Antibody bait and switch catalysis: A survey of antigens capable of inducing abzymes with acyl-transfer properties", J. Am. Chem. Soc. 1991, 113:5427-5434.
E. Baldwin and P. G. Schultz, "Generation of a catalytic antibody by site-directed mutagenesis", Science 1989. 245:1104-1107.
K. D. Janda et al., "Substrate attenuation: An approach to improve antibody catalysis", Tetrahedron 1991, 47:2503-2506.
I. Fujii, et al., "Enantiofacial protonation by catalytic antibodies", J. Am. Chem. Soc. 1991, 113:8528-8529.
J. Ambre, et al., "Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans", J. Analytical Toxicology 1984, 8:23-25.
J. Ambre, "The urinary excretion of cocaine and metabolites in humans: A kinetic analysis of published data", J. Anal. Toxicol. 1985, 9:241-245.
P. G. Schultz, "The interplay between chemistry and biology in the design of enzymatic catalysts", Science 1988, 240:426-433.
C. B. Carpenter, "Immunosuppression in organ transplantation", N. Engl. J. Med. 1990. 332:1224-1226.
E. J. Ziegler, et al., "Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxic", N. Engl. J. Med 1991, 324:429-436.
R. D. Mayforth and J. Quintans, "Designer and catalytic antibodies", New Eng. J. Med. 1990, 323:173-178.
L. M. Reichmann et al., "Reshaping human antibodies for therapy", Nature 1988, 332:323-327.
C. Queen et al., "A humanized antibody that binds to the interleukin 2 receptor", Proc. Natl. Acad. Sci USA 1989 86:10029-10033.
M. J. Chow, et al., "Kinetics of cocaine distribution, elimination, and chronotropic effects", Clin. Pharmacol. Ther. 1985, 38:318-324.
S. Ikeda et al., "Asymmetric induction via a catalytic antibody", J. Am. chem. Soc. 1991, 113:7763-7764.
R. A. Dean et al., "Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine", FASEB J. 1991, 5:2735-2739.
M. Benuck et al., "Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice", J. Pharmacol. Exp. Therap. 1987. 243:144-149.

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