Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-11-12
2009-08-18
Cook, Lisa V (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S512000, C436S547000, C435S007210, C435S070210, C424S130100, C530S300000, C530S350000, C530S387100
Reexamination Certificate
active
07575873
ABSTRACT:
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine their relative pathology. As the method is based on a human Fab rather than a mouse Mab, the progress or regression of the disease may be monitored over time. The antibody may also be used for the analysis of surgical or serum samples ex vivo for the presence of OxLDL. The antibody may also be used to target therapeutic agents to the site of atherosclerotic plaques or may have use as a therapeutic agent itself.
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Palinski Wulf
Tsimikas Sotirios
Witztum Joseph L.
Baker, Jr. Joseph R.
Cook Lisa V
Gavrilovich Dodd & Lindsey LLP
The Regents of the University of California
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