Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Boron containing doai
Reexamination Certificate
2008-02-21
2010-12-28
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Boron containing doai
C548S405000, C548S428000, C548S429000, C544S229000, C544S234000
Reexamination Certificate
active
07858598
ABSTRACT:
Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.
REFERENCES:
patent: 2005 053900 (2005-03-01), None
patent: WO 01/64664 (2001-09-01), None
English abstract of B1, Dated Sep. 7, 2001, Nagano et al.
English abstract of B3, Dated Mar. 3, 2005, Toray Ind Inc.
Bemofsky, C., FASEB J., 1991, 5, 295-300.
Gabe et al., J. Am. Chem. Soc., 2004, vol. 126, No. 10, 3359.
Gould, J. P.; Richards, J. T.; Miles, M. G., Water Res., 1984, 18, 205-212.
Gould, J. P.; Richards, J. T.; Miles, M. G., Water Res., 1984, 18, 991-999.
Hattori et al., J. Phys. Chem. B., 2005, 109, 15368-15375.
Hawkins, C. L.; Davies, M. J., Chem. Res. Toxicol., 2002, 15, 83-92.
Hayatsu, H.; Pan, S.-K.; Ukita, T., Chem. Pharm. Bull. , 1971, 19, 2189-2192.
Hazell, L. J.; Stocker, R., Biochem. J., 1993, 290, 165-172.
Hazell, L. J.; van den Berg, J. J.; Stocker, R., Biochem. J., 1994, 302, 297-304.
Hazen, S. L.; Heinecke, J. W., J. Clin. Invest., 1997, 99, 2075-2081.
Hughes, M. N.; Nicklin, H. G., J. Chem. Soc. (A), 1968, 2, 450-452.
Keith, W. G.; Powell, R. E., J. Chem. Soc. (A), 1969, 1, 90.
Lapenna, D.; Cuccurullo, F., Gen. Pharmacol., 1996, 27, 1145-1147.
McKenna, S. M.; Davies, K. J. A., Biochem. J., 1988, 254, 685-692.
Miura et al., J. Am. Chem. Soc., 2003, vol. 125, No. 28, 8667.
Osuka et al., J. Am. Chem. Soc., 1990, 112, 4958-4959.
Owton, J. Chem. Soc., Perkin Trans. 1, 1999, 2409-2420.
Patton, W.; Bacon, V.; Duffield, A. M.; Halpern, B.; Hoyano, Y.; Pereira, W.; Lederberg, J., Biochem. Biophys. Res. Commun., 1972, 48, 880-884.
Prutz, W. A., Arch. Biochem. Biophys., 1996, 332, 110-120.
Prutz, W. A., Arch. Biochem. Biophys., 1998, 349, 183-191.
Prutz, W. A., Arch. Biochem. Biophys., 1999, 371, 107-114.
Sakata et al., J. Am. Chem. Soc., 1994, 116, 6904-6909.
Setsukinai, K.; Urano, Y.; Kakinuma, K.; Nagano, T., J. Biol. Chem. 2003, 278, 3170-3175.
Thomas, E. L., Infect. Immun., 1979, 23, 522-531.
Toyota et al, Langmuir, 2006, 22, 1976-1981.
Vissers, M. C. M.; Winterboum, C. C., Arch. Biochem. Biophys., 1991, 285, 53-59.
Winterbourn, C. C.; Kettle, A. J., Free Radical Biol. Med., 2000, 29, 403-409.
Notification of Transmittal of the International Preliminary Report of PCT/CN2008/000449, mailed on Jun. 12, 2008.
International Search Report of PCT/CN2008/000449, mailed on Jun. 12, 2008.
Written Opinion of PCT/CN2008/000449, mailed on Jun. 12, 2008.
Chen Yan
Liu Fengqin
Sun Zhen-Ning
Yang Dan
Barker Michael
Chu Yong
Morningside Ventures Limited & Versitech Limited
Saliwanchik Lloyd & Saliwanchik
LandOfFree
Reagents for detection of hypochlorous acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reagents for detection of hypochlorous acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagents for detection of hypochlorous acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4205123