Reagents and methods utilizing labeled Fab bound to antigens

Details Reagents and methods utilizing labeled Fab bound to antigens Reagents and methods utilizing labeled Fab bound to antigens

1979-08-21

1981-11-03

Kyle, Deborah L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 260112B, 424 12, 435 7, A61K 4300, G01N 3348, G01T 100

Patent

active

042985935

ABSTRACT:
This invention involves an improvement in a method for immunochemically assaying a member of an antigen-antibody binding pair in serum or plasma which utilizes labeled antigen having a plurality of antigenic binding sites as the indicating reagent, the improvement comprising employing the antigen immunochemically bound to labeled Fab as the indicating reagent. This invention also encompasses reagents useful in practicing the above method. These methods and reagents are particularly useful in hepatitis detection.

REFERENCES:
patent: 4166106 (1979-08-01), Sedlacek et al.
patent: 4193982 (1980-03-01), Avrameas et al.
Gonatas et al., J. Histochem. Cytochem., 22 #11 1974, pp. 999-1009.
Zaitlin, Immunochem., 8(6) 1971, pp. 569-573._

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