Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-08
2000-08-29
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 723, 435 912, 435 915, 435 9151, 436504, 536 2431, 536 2433, 536 245, 536 231, C12Q 170, C12P 1934, G01N 3353, C07H 2104
Patent
active
061106755
ABSTRACT:
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
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Cohen Maurice
Friedman Paula N.
Gordon Julian
Hodges Steven C.
Klass Michael R.
Abbott Laboratories
Bansal Geetha P.
Becker Cheryl L.
Goller Mimi C.
Huff Sheela
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