Reagents and methods for the diagnosis and treatment of diabetes

Details Reagents and methods for the diagnosis and treatment of diabetes Reagents and methods for the diagnosis and treatment of diabetes

1995-05-25

1998-12-15

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 793, 436506, 436518, G01N 33531, G01N 33543, G01N 33564

Patent

active

058495061

ABSTRACT:
The invention provides fragments of GAD.sub.65 that are specifically reactive with at least one class of GAD.sub.65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD.sub.65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.

REFERENCES:
Christie et al., Distinct Antibody Specificities to a 64 kD-Islet Cell Antigen in Type 1Diabetes as Revealed by Trypsin Treatment, J. Exp. Med. 172:789-794, 1990.
Baekkeskov et al., Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase, Nature 347:151-156, 1990.
Richter et al., Autoreactive eptiopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase, Proc. Natl. Acad. Sci. USA 90:2832-2836, 1993.
Christgau et al., Membrane Anchoring of the Autoantigen GAD65 to Microvesicles in Pancreatic -62 -cells by Palmitoylation in the NH2-Terminal Domain, J. Cell Biol. 118(2):309-320, 1992.

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