Reagents and methods for the diagnosis and treatment of diabetes

Details Reagents and methods for the diagnosis and treatment of diabetes Reagents and methods for the diagnosis and treatment of diabetes

1997-10-10

1999-12-07

Wortman, Donna C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 693, 435 703, 436506, 436811, C07K 1447

Patent

active

059985844

ABSTRACT:
The invention provides fragments of GAD.sub.65 that are specifically reactive with at least one class of GAD.sub.65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD.sub.65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.

REFERENCES:
patent: 5674978 (1997-10-01), Tobin et al.
patent: 5691448 (1997-11-01), Baekkeskov et al.

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