Reagents and methods for the detection and qualification of thyr

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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530807, C07K 1700

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active

056889216

ABSTRACT:
Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: ##STR2## wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.

REFERENCES:
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patent: 4888296 (1989-12-01), Sieber et al.
M. Bhattacharya et al., Chem. Abstracts, vol. 110, No. 147,996, abstract of Indian J. Exp. Biol, vol. 26, No. 12, pages 990-992 (1988).

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