Reagents and methods for smooth muscle therapies

Details Reagents and methods for smooth muscle therapies Reagents and methods for smooth muscle therapies

2006-11-14

2006-11-14

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S013800, C514S014800, C514S015800, C514S016700, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000

Reexamination Certificate

active

07135453

ABSTRACT:
The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.

REFERENCES:
patent: 5710172 (1998-01-01), Kukreja et al.
patent: 6475490 (2002-11-01), Srivastava et al.
patent: 2004/0192592 (2004-09-01), Weiner et al.
patent: WO 91/15219 (1991-10-01), None
patent: WO 98/53061 (1998-11-01), None
Ngo et al. Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox. The protein folding problem and Tertiary Structure Prediction. Ed. K. merz and L. Le Grand. Birkhauser, Boston, Ma. pp. 491-495. 1994.
Rudinger, J. (1976). Peptide Hormones (Ed. J. A. Parsons). University Park Press. Baltimore. pp. 1-7.
Berendsen, Herman. “A Glimpse of the Holy Grail?” Science. vol. 282, pp. 642-643. Oct. 23, 1998.
Akamatsu, et al., (1997), Bioorg Med Chem, “Potent Inhibition of Protein-Tyrosine Phosphatase by Phosphotyrosine-Mimic Containing Cyclic Peptides”, vol. 5 (1), pp. 157-163.
Anderson, P., et al., (2000), Arterioscler Thromb Vasc Biol, Cyclic GMP-dependen protein kinase expression in coronary arterial smooth muscle in response to balloon catheter injury. , vol. 20, pp. 2191-2197.
Beall, A., et al., (1997), The Journal of Biological Chemistry, “Cyclic Nucleotide-dependent Vasorelaxation is Associated with the Phosphorylation of a Small Heat Shock-related Protein”, vol. 272, (17), pp. 11283-11287.
Beall, A., et al., (1999), The Journal of Biological Chemistry, “The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation”, vol. 274, (16), pp. 11344-11351.
Bergh, C., et al., (1995), The American Physiological Society, “Impaired Cyclic Nucleotide-dependent Vasorelaxation in Human Umbilical Artery Smooth Muscle”, vol. 268, pp. H202-H212.
Boerth, N., et al., (1997), J. Vasc. Res., Cyclic GMP-deendent protein kinase regulates vascular smooth muscle cell phenotype., vol. 34, pp. 245-259.
Brophy, C., et al., (1999), The Journal of Biological Chemistry, “Phosphorylation of the Small Heat Shock-related Protein, HSP20, in Vascular Smooth Muscles is Associated with Changes in the Macromolecular Associations of HSP20”, vol. 274, (10), pp. 6324-6329.
Brophy, C., et al., (1998), Journal of reproduction and Fertility, “Heat shock protein expression in umbilical artery smooth muscle”, vol. 114, pp. 351-355.
Brophy, C. et al., (1997), Biology of Reproduction, “Small Heat Shock Proteins and Vasospasm in Human Umbilical Artery Smooth Muscle”, vol. 57, pp. 1354-1359.
Brophy, C., et al., (1997), The Basic Science of Vascular Disease, “Regulation of Vasomotor Tone and Vasospasm”, Chapter 13, pp. 367-384.
Brophy, C., et al., (1997), Journal of Vascular Surgery, “Cellular mechanisms of cyclic nucleotide-induced vasorelaxation”, vol. 25, (2), pp. 390-397.
Brophy, C., et al., (1999), Journal of Vascular Surgery, “The small heat shock-related protein-20 is an actin-associated protein”, vol. 29(2), pp. 326-333.
Brophy, C., et al., (2000), Surgery, “The macromolecular associations of heat shock protein-27 in vascular smooth muscle”, vol. 128 (2), pp. 320-326.
Brophy,C., (2000), Journal of Vascular Surgery, Invited Basic Science Review, “The dynamic regulation of blood vessel caliber”, vol. 31 (2), pp. 391-396.
Brophy, C., et al., (2001), Journal of Vascular Research, Internet Discussion Forum, “cGMP-Dependent Protein Kinase Expression Restores Contractile Function in Cultured Vascular Smooth Muscle Cells”, vol. 39, pp. 95-103.
Brophy, C., (2002), World J. Surg, “Stress and Vascular Disease at the Cellular and Molecular Levels”, vol. 26, pp. 779-782.
Carpino and Han, (1972), J. Org. Chem., “The 9-Fluorencylmethoxycarbonyl Amino-Protecting Group”, vol. 37, pp. 3403-3409.
Fawell, S., et al., (1994), Proc Natl Acad Sci USA, “Tat-mediated delivery of heterologous proteins into cells,”, vol. 91, pp. 664-668.
Francy, A., et al., (1999), Biochemical and Biophysical Research Communications, “Rat Hsp20 Confers Thermoresistance in a Clonal Survival Assay, but Fails to protect Coexpressed Luciferase in Chinese Hamster Ovary Cells”, vol. 254, pp. 164-168.
Frankel, A., et al., (1988), Cell, “Cellular uptake of the tat protein from human immunodeficiency cirus”, vol. 55, 1189-1193.
Fuchs, L., et al., (2000), Am J. Physiol Regulatory Integrative Comp Physiol, “Stress cases decrease in vascular relaxation linked with altered phosphorylation of heat shock proteins”, vol. 279, pp. R492-R498.
Green, M., et al., (1988), Cell, “Autonomous Functional Domains of Chemically Synthesized Human Immunodeficiency Virus Tat Trans-Activator Protein”, vol. 55, pp. 1179-1188.
Hedges, J., et al., (1999), The Journal of Biological Chemistry, “A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration”, vol. 274, (34), pp. 24211-24219.
Ho, A., et al., (2001), Cancer Res., “Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo”, vol. 61, pp. 474-477.
Inaguma, Y., et al., (1996), Gene, “cDNA cloning of a 20-kDa protein (p20) highly homologous to small heat shock proteins: developmental and physiological changes in rat hindlimb muscles”, vol. 178, pp. 145-150.
Jerius, H., et al., (1999), J. Vasc. Surg, Endothelial-dependent vasodilation is associated with increases in the phosphorylation of a small heat shock protein (HSP20), vol. 29, pp. 678-684.
Kato, K., et al., (1994), The Journal of Biological Chemistry, Purification and Characterization of a 20-kDa Protein that is Highly Homologous to Crystallin, vol. 269, (21), pp. 15302-15309.
Knoepp, et al., (1999), Surgical Forum, “Cellular stress inhibits smooth muscle relaxation”,Surgical forum, vol. 50, pp. 432-433.
Knoepp, et al., (1999), J. Vasc. Surg., “Cellular stress inhibits vascular smooth muscle relaxation”, vol. 31, pp. 343-353.
Komalavilas, P., et al., (2001), J. Appl. Physiol, PI3-kinase/Akt modulates vascular smooth muscle tone via camp signaling pathways, vol. 91, pp. 1819-1827.
Lavoie, J. et al., (1995), Molecular and Cellular Biology, “Modulation of Cellular Thermoresistance and Actin Filament Stability Accompanies Phosphorylation-Induced Changes in the Oligomeric Structure of Heat Shock Protein 27”, vol. 15 (1), pp. 505-516.
Macomson, et. al., (2002), Neurosurgery, “Heat shock protein expression in cerebral vessels after subarachnoid hemorrhage”, vol. 51, pp. 204-211.
Matsuno, H., et al., (1998), FEBS Letters, “A heat shock-related protein, p20, plays and inhibitory role in platelet activation”, vol. 429, pp. 327-329.
Merrifield, R.B., (1963), J. Am. Chem. Soc., “Solid Phase Peptide Syntheseis. I. The Synthesis of a Tetrapeptide”, vol. 85, pp. 2149-2154.
Niwa, M., et al., (2000), Elsevier Life Sciences, “Small Molecular Weight Heat Shock-related Protein, HSP20, Exhibits and Anti-Platelet Activity by Inhibiting Receptor-Mediated Calcium Influx”, vol. 66 (1), pp. PL7-PL12.
O'Connor, M., et al., (2002), J. Appl. Physiol., “Heat-induced force suppression and HSP20 Phosphorylation in Swine carotid media”, vol. 93, pp. 484-488.
Otaka, A., et al., (1995), Pergamon, Tetrahedron Letters, Elsevier Science Ltd., “Synthesis and Application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for Solid-Phase Synthesis of Nonhydrolyzable Phosphoserine Peptide Analogues”, vol. 36, (6), pp. 927-930.
Rembold, C., et al., (2001), BMC Physiology, “Localization of heat shock protein 20 in swine carotid artery”, vol. 1(10).
Rembold, C., et al., (2000), Elsevier Biochimica et Biophysica Acta, “Caldesmon and heat shock protein 20 phosphoryla

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