Reagents and methods for mycophenolic acid immunoassay

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

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C435S007910, C435S007920, C435S188000, C436S518000, C436S544000, C436S546000, C530S388900, C530S389800, C530S406000

Reexamination Certificate

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07138504

ABSTRACT:
The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to MPA with cross-reactivity of no more than 5% with inactive metabolites and commonly co-prescribed drugs. Further, immunoassays for measuring the concentration of MPA using such antibodies are taught.

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes by M. Shipkova et al; British Journal of Pharmacology (2001); pp. 1027-1034.

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