Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-06-27
1998-04-07
Guzo, David
Chemistry: molecular biology and microbiology
Spore forming or isolating process
536 245, C12N 508, C07H 2102
Patent
active
057362947
ABSTRACT:
Expression of genes may be modulated by employment of compositions which are capable of RNA mimicry. A portion of RNA coded by the gene whose expression is to be modulated is selected which is capable of interacting with one or more proteins. An oligonucleotide or oligonucleotide analog is then prepared in such a way as to mimic the portion of the RNA. Cells containing the gene are then contacted with the oligonucleotide or oligonucleotide analog to effect the modulation. Therapeutic compositions and methods, especially for the treatment of human immunodeficiency, are disclosed.
REFERENCES:
Hawley-Nelson et al. "The Specific DNA Recognition Sequence of the Bovine Papillomavirus E2 Protein is an E2-Dependent Enhancer", EMBO Journal, vol. 7, No. 2, pp. 525-531, 1988.
P.S. Sarin et al., "Inhibition of Acquired Immunodeficiency Syndrome Virus by Oligonucleoside Methylphosphonates", Proc. Natl. Acad. Sci., Oct. 1988, vol. 85, No. 20, pp. 7448-7451.
J. Lisziewics et al., "Repression of the TAT Function Through Multiple TAR RNA Sequences", J. Cell. Biochemistry, 1990, vol. 14D, p. 123.
Agrawal et al., Proc. Natl. Acad. Sci. USA 86:7790 (1989).
Berkhout, Cell 59:273 (1989).
Buck et al., Science 248:208 (1990).
Casey et al., Science 240:924 (1988).
Dayton et al., Science 246:1625 (1989).
Dayton et al., J. Acq. Immune Deficiency Syndromes, 1:441 (1988).
Ensoli et al., Nature, 345:84-86 (1990).
Feng, E.C. Holland, Nature 334:165 (1988).
Felber B.K. and Pavlakis G.N. (Science, 239:184-187 (1988).
Garcia et al., EMBO J. 8:765 (1989).
Graham et al., Proc. Natl. Acad. Sci. USA 87:5817-5821 (1990).
Haseltine, F. Wong-Staal, Scientific American, 259:52 (1988).
Henthorn et al., Proc. Natl. Acad. Sci. USA 85:6342 (1988).
Iyer et al., J. Am. Chem. Soc. (1990) 112:1253-1254.
Knapp, Methods Enzymol. 180:192 (1989).
Laspia et al., Cell 59:283 (1989).
Larson, B.H. Sells, Mol. Cell. Biochem. 74:5 (1987).
Le et al., Nucl. Acids Res. 16:5153 (1988).
Letsinger et al., Proc. Natl. Acad. Sci. USA 86:6553 (1989).
Malter, Science 246:664 (1989).
Matsukura et al., Proc Natl. Acad. Sci. USA, 84:7706 (1987).
Mori et al., Nucleic Acids Res. 17:8207 (1989).
Ratner et al., Nature 313:277 (1985).
Resnekov et al., J. Biol. Chem. 264:9953 (1989).
Sarin et al., Proc. Natl. Acad. Sci. USA 85:7448 (1988).
Shibahara et al., Nucl. Acids Res. 17:239 (1989).
Stevenson, P.L. Iversen, J. Gen. Virol. 70:2673 (1989).
Sharp, and R.A. Marciniak, Cell 59:229 (1989).
Sabatier et al., J. Virol., 65:961-967 (1991).
Salahuddin et al., Science, 242:430-433 (1988).
Tom, Hawaii Med. J., 48:131-134 (1989).
Tinoco et al., Cold Spring Harb. Symp. Quant. Biol. 52:135 (1987).
Tuerk et al., Proc. Natl. Acad. Sci. U. S. A. 85:1364 (1988).
Vogel et al., Nature, 335:606-611 (1988).
Viscidi et al., Science, 246:1606-1608 (1989).
Zuker, Science, 244:48 (1989).
Bruice Thomas W.
Ecker David J.
Vickers Timothy A.
Guzo David
ISIS Pharmaceuticals Inc.
LandOfFree
Reagents and methods for modulating gene expression through RNA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reagents and methods for modulating gene expression through RNA , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagents and methods for modulating gene expression through RNA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-11278