Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Reexamination Certificate
2005-03-25
2008-10-14
Le, Long V. (Department: 1641)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
C422S082050, C422S082060, C422S082070, C435S006120, C435S007100, C435S007500, C436S172000
Reexamination Certificate
active
07435386
ABSTRACT:
The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor-operates without additional development reagents, requiring only the presence of analyte or target for function.
REFERENCES:
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 5194393 (1993-03-01), Hugl et al.
patent: 2002/0012951 (2002-01-01), Strittmatter
Cull et al., “Biotinylation of proteins in vivo and in vitro using small peptides tags,” Methods in Enzymology, 2000, vol. 326, pp. 430-440.
Jakeway et al., “Consideration of end effects of DNA hybridization in selection of fluorescent dyes for development of optical biosensors,” Canadian J. Chem., 1999, vol. 77, pp. 2083-2087.
Liu et al., “Molecular beacons for DNA biosensors with micrometer to submicrometer dimensions,” Anal. Biochem., 2000, vol. 283, pp. 56-63.
Medintz et al., “A fluorescence resonance energy transfer sensor based on maltose binding protein,” Bioconjugate Chem., 2003, vol. 14, pp. 909-918.
Niemeyer et al., “DNA-directed immobilization: efficient reversible, and site selective surface binding of proteins by means of covalent DNA-streptavidin conjugates,” Anal. Biochem., 1999, vol. 268, pp. 54-63.
Schmidt et al.., “Real-time determination of telomerase activity in cell extracts using an optical biosensor,” Biol. Chem., 2002, vol. 383, pp. 1659-1666.
Sharff et al., “Refined 1.8-A structure reveals the mode of binding beta-cyclodextrin to the maltodextrin binding protein,” Biochem., 1993, vol. 32, pp. 10553-10559.
Scheller, et al.,Curr. Opin. Biotech. 2001, 12, 35-40.
Iqbal, etalBiosens. Bioelect. 2000, 15, 549-578.
O'Connell, P.J; Guilbault, G.G.Anal. Lett. 2001, 34, 1063-1078.
Marvin, J.S.; Corcoran, E.E.; Hattangadi, N.A.; Zhang, J.V.; Gere, S.A.; Hellinga, H.W.Proc. Natl. Acad. Sci. USA1997, 94, 4366-4371.
Andreotti, P.E.; Ludwig, G.V.; Peruski, A.H.; Tuite, J.J.; Morse, S.S.; Peruski, L.F,BioTechniques2003, 35, 850-861.
Peruski, L.F; Peruski, A.H.BioTechniques2003, 35, 840-846.
Nakamura, H.; Karube, I.Anal. Bioanal. Chem. 2003, 377, 446-468.
Baeumner, A.J.Anal. Bioanal. Chem. 2003, 377, 434-445.
De Lorimier, R.M.; Smith, J.J.; Dwyer, M.A.; Looger, L.L.; Sali, K.M.; Paavola, C.D.; Rizk, S.S.; Sadigov, S.; Conrad, D.W.; Loew, L.; Hellinga, H.W.Prot. Science2002, 11, 2655-2675.
Marvin, J.S.; Hellinga, H.W.Nature Struct. Bio. 2001, 8, 795-798.
Benson, D.E.; Conrad, D.W.; de Lorimer, R.M.; Trammel, S.A.; Hellinga, H.W.Science2001, 293, 1641-1644.
Looger, L.L.; Dwyer, M.A,; Smith, J.J.; Hellinga, H.W.Nature2003, 423, 185-189.
Hellinga, H.W.; J.S. Marvin. Trends Biotech. 1998, 16, 183-189.
Wada, A.; Mie, M.; Aizawa, M.; Lahoud, P.; Cass, A. E. G.; Kobatake, E.J.A.C.S. 2003, 52, 16228-16234.
Fehr, M.; Frommer, W.B.; Lalonde, S.Proc. Natl. Acad. Sci. USA2002, 99, 9846-9851.
Fehr, M.; Lalonde, S.; Lager, I.; Wolff, M.W.; Frommer, W.B.J. Biological Chem. 2003, 278, 19127-19133.
Medintz, I.L.; Goldman, E.R.; Lassman, M.E.; Mauro, J.M.Bioconjug. Chem. 2003, 14, 909-918.
Medintz, I.L.; Clapp, A.R.; Mattoussi, H.; Goldman, E.R.; Fisher, B.; Mauro, J.M.Nature Mat. 2003, 2, 630-638.
Lichlyter, et al.,Biosen. Bioelect. 2003, 19, 219-226.
Maxwell, et al.,J. Am. Chem. Soc. 2002, 124, 9606-9612.
Gilardi, et al.,Anal. Chem. 1994, 66, 38403847.
Niemeyer, et al.,Bioconjug. Chem. 1998, 9, 168-175.
Niemeyer, et al.,Anal. Biochem. 1999, 268, 5463.
Goldman, et al.,Anal. Chem. 2002, 274,841-84.
Sharff, et al.,Biochem. 1993, 32, 10553-10559.
Medintz, et al.,Anal. Lett. 2004, 37, 191-202.
Steel, A.B.; Levicky, R.L.; Herne, T.M.; Tarlov, M.J.Biophysical J. 2000, 79, 975-981.
Holmberg, et al.,Ultramicroscopy2003, 97, 257-261.
Cull, et al.,Methods in Enzymology, 2000 Eds. Thorner, J.; Emr, S.D.; Abelson, J.N. (Academic Press, NY), pp. 430-440.
Russell, et al., Anal. Chem. 1999, 71, 3126-3132.
Ueda, et al., Morganti, L.J. Chromatog. A. 2003, 988, 1-23.
Saghatelian, et al.,J.A.C.S. 2003, 125, 344-345.
Hossain, et al., Guest-Induced Diminishment in Fluorescence Quenching and Molecule Sensing Ability of a Novel Cyclodextrin-Peptide Conjugate.J. Am. Chem. Soc. 123, 7435-7436, 2001.
Hossain et al., Association of alpha-helix peptides that have gamma-cyclodextrin and pyrene units in their side chain, and induction of dissociation of the association dimer by external stimulant moleculesJ. Chem. Soc Perkin Trans. 2 (7): 1527-1533 2000.
Pagliari, et al., Enantioselective Sensing of Amino Acids by Copper(II) Complexes of Phenylalanine-based Fluorescent β-Cyclodextrins.Tetrahedron Letters41, 3691-3695. 2000.
Tong, et al., Boronic Acid Fluorophore/β-Cyclodextrin Complex Sensors for Selective Sugar Recognition in Water.Anal. Chem. 73, 1530-1536, 2001.
Tanabe, et al., Immobilized Fluorescent Cyclodextrin on a Cellulose Membrane as a Chemosensor for Molecule Detection.Anal. Chem. 73, 3126-3130, 2001.
Tanabe et al., Fluorescent cyclodextrin immobilized on a cellulose membrane as a chemosensor system for detecting moleculesAnal. Chem73 (8): 1877-1880, 2001.
Gambhir et al., Covalent immobilization of urease on polypyrrole microspheres for application as a urea biosensorE-Polymersart. No. 052 Nov. 22, 2002.
Chang et al., (2002) Disposable tyrosinase-peroxidase bi-enzyme sensor for amperometric detection of phenolsBiosens. Bioelect. 17 (11-12): 1015-1023 Sp. Iss. Sl Dec.
Denizli et al., (2001) Dye-ligand affinity systemsJ. Biochem. Biophys. Meth. 49 (1-3): 391-416 Oct. 30.
Delehanty et al., (2002). A microarray immunoassay for simultaneous detection of proteins and bacteriaAnal. Chem74 (21): 5681-5687 Nov. 1.
Samoylov et al., Peptide biosensor for recognition of cross-species cell surface markers (2002)J. Mol. Recog. 15 (4): 197-203 Jul.-Aug.
Ditzler, et al., (1995). The impact of tether hydrophobicity on stoichiometry of immobilized indicator-analyte complexes.Anal. Chim. Acta316 (3): 391-402 Dec. 11.
Ditzler, et al., (1991) Photometric probe for studying substrate tether systemsAnal. Chim. Acta(1): 103-108 Feb. 15 vol. 243.
Gorelik et al., (2001) Shuttle electron transfer in tethered mediator biosensor.Sens. Actuat. B-Chem. 80 (3): 179-182 Dec.
Baas et al., (2002) Characterization of a cysteine-containing peptide tether immobilized onto a gold surface.Langmuir18 (12): 4898-4902 Jun.
Steel, et al., (2000) Immobilization of nucleic acids at solid surfaces:effect of oligonucleotide length on layer assemblyBiophys. J. 79 (2) 975-981.
Niemeyer et al., (1998) Hybridization characteristics of biomolecular adaptors, covalent DNA streptavidin conjugatesBioconjug. Chem. 9 (2): 168-175 Mar.-Apr.
Niemeyer, et al., (1999). DNA-directed immobilization: Efficient, reversible, and site-selective surface binding of proteins by means of covalent DNA-streptavidin conjugatesAnal. Biochem. 268 (1): 54-63.
Liu et al., (2000) Molecular beacons for DNA biosensors with micrometer to submicrometer dimensions.Anal. Biochem283 (1): 56-63 Jul. 15.
Schmidt et al., (2002) Real-time determination of telomerase activity in cell extracts using an optical biosensorBio. Chem. 383 (10): 1659-1666 Oct.
Jakeway et al., (1999) Consideration of end effects of DNA hybridization in selection of fluorescent dyes for development of optical biosensors.Can. J. Chem. (12): 2083-2087 Dec. 1999 vol. 77.
Cavic et al., (2001) High surface density immobilization of oligonucleotide on silicon.Analyst126 (4): 485-490
Anderson George P.
Goldman Ellen R.
Mauro J. Matthew
Medintz Igor L.
Jung Unsu
Karasek John A
Le Long V.
Ressing Amy
The United States of America as represented by the Secretary of
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