Reagent test strip for determination of blood glucose

Details Reagent test strip for determination of blood glucose Reagent test strip for determination of blood glucose

1998-03-16

1999-10-26

Alexander, Lyle A.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

422 61, 436177, 436 95, G01N 3348, C12Q 154

Patent

active

059722940

ABSTRACT:
A reagent test strip is adapted for use in a blood glucose meter. A sample of whole blood is applied to one surface of a matrix on the strip and the meter measures the reflectance of the opposite surface of the matrix at about 635 nm and 700 nm and calculates from the reflectance the concentration of glucose in the sample. The portion of the applied sample that penetrates the matrix and is visible from the testing surface does not absorb light to any appreciable extent at 700 nm. Nevertheless, the glucose-containing sample interacts with the components of the reagent-containing matrix to cause a change in reflectance at 700 nm that simulates the effect of the blood color. As a result, the strip can be used in meters that measure glucose concentration in whole blood samples in the presence of optically visible hemoglobin.

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Capaldi, Dante J. and Taylor, Keith E. Analytical Biochemistry 129,329-336 (1983) "A new Peroxidase Color Reaction: Oxidative Coupling of 3-Methyl-2-Benzothiazolinone Hydrazone (MBTH) with its Formaldehyde Azine. Application to Glucose and Choline Oxidases".

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