Reagent for the determination of water AMD ene-diols or thiols

Details Reagent for the determination of water AMD ene-diols or thiols Reagent for the determination of water AMD ene-diols or thiols

1996-08-12

1998-05-12

Snay, Jeffrey

Chemistry: analytical and immunological testing

Determination of water

By use of a karl fischer reagent

G01N 3318

Patent

active

057504040

ABSTRACT:
Novel reagents and the rapid technique were developed for the simultaneous determination of water and ene-diols or thiols in chemical products, drugs and other materials which are inaccessible for direct K. Fischer titration. The reagents include iodine, tetramethylammonium iodide or potassium iodide, non-toxic organic or inorganic base adapted to provide a pH in range of 5.5 to approximately 8.0 (diethanolamine, thriethanolamine, sodium acetate or/and urea) in methanol or another alcohol mixed with N,N-dimethyl-formamide, or with formamide, or with dimethyl sulfoxide and N,N dimethylformamide mixture as a solvent. The use of the reagents is based on the consecutive titration first a) of an ene-diol or thiol by the novel reagents and then b) of water by a conventional K. Fischer reagent in the same cell in a system protected from water vapour and oxygen, with the help of the double burette for electrometric location of the end point in both titrations (or a multistage titroprocessor).

REFERENCES:
patent: 4740471 (1988-04-01), Scholz
patent: 4874709 (1989-10-01), Fischer et al.
patent: 5179024 (1993-01-01), Dahms
patent: 5340541 (1994-08-01), Jackson et al.
patent: 5466606 (1995-11-01), Scholz
patent: 5567618 (1996-10-01), Scholz
Sherman, F. et al. Talanta, vol. 43 (Jul., 1996), pp. 1035-1042.

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