Compositions – Compositions containing a single chemical reactant or plural... – Organic reactant
Patent
1989-07-25
1990-08-21
Miller, Edward A.
Compositions
Compositions containing a single chemical reactant or plural...
Organic reactant
530335, C09K 300
Patent
active
049504185
ABSTRACT:
Reagent for removing protective groups employed in peptide synthesis comprises a combination of hard acid and soft base. The hard acid is trialkylsilyltrifluoromethanesulphonate R.sub.3 SiO.sub.3 SCF.sub.3 and the soft base is ether. The reagent provides high efficiency of deprotection and has a low tendency to cause side reaction.
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Fujii et al., J. Chem. Soc., Chemical Communications, 1987, (#4), 274-275, (Feb. 1987).
Fujii et al., Chem. & Pharm. Bull., 35, (#3), 1266-1269, (Mar. 1987).
"Synthetic Studies on Peptides Using Organosulfonic Acids-Deprotecting Procedure", 103, Yakugaku Zasshi, 805-818, (1983).
"Acidolytic Deprotecting Procedures in Peptide Synthesis", H. Yajima and N. Fuji, The Peptides, vol. 5, 1983.
Fujii Nobutaka
Guterres Gilberto M. A.
Honguu Tatsuhiko
Yajima Haruaki
Miller Edward A.
Shin-Etsu Chemical Co. , Ltd.
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