Reagent for quantitative determination of small, dense LDLs

Details Reagent for quantitative determination of small, dense LDLs Reagent for quantitative determination of small, dense LDLs

2008-02-28

2011-10-04

Wallenhorst, Maureen (Department: 1777)

Chemistry: analytical and immunological testing

Lipids, triglycerides, cholesterol, or lipoproteins

C436S013000, C436S174000, C436S175000, C435S011000, C435S019000, C435S027000

Reexamination Certificate

active

08030081

ABSTRACT:
A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further provided. The method includes first step of eliminating lipoproteins other than small, dense LDLs in a sample in the presence of cholesterol esterase and 0.05 g/L to 1.0 g/L of a surfactant that acts on the lipoproteins other than small, dense LDLs, and a second step of quantitatively determining cholesterol in small dense LDLs that remain after the first step.

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