Reagent for determining laminin 5 antigen in biological...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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10487321

ABSTRACT:
A method of determining a laminin 5 antigen in a biological sample, comprising the steps of bringing an antibody reactive to a laminin 5 γ2 chain N-terminal fragment into contact with the biological sample; measuring a reaction of the antibody; and determining an amount of the laminin 5 antigen based on a measurement result of the reaction, as well as, a method of detecting a laminin 5-producing tumor cell, a method of examining acute respiratory distress syndrome and a method of evaluating malignancy of a malignant tumor based on the assay method.

REFERENCES:
patent: 5445948 (1995-08-01), Shimizu et al.
patent: 6143505 (2000-11-01), Tryggvason et al.
patent: 2001-172196 (2001-06-01), None
Koshikawa, et al., “Overexpression of Laminin γ2 Chain Monomer in Invading Gastric Carcinoma Cells”Cancer Research, 59: 5596-5601, 1999.
Manda, et al., “Differential Expression of the LAMB3 and LAMC2 Genes Between Small Cell and Non-Small Cell Lung Carcinomas”,Biochemical and Biophysical Research Communications, 275: 440-445, 2000.
Palacios, et al., “The Short Arm of the Laminin γ2 Chain Plays a Pivotal Role in the Incorporation of Laminin 5 into the Extracellular Matrix and in Cell Adhesion”,The Journal of Cell Biology, 153(4): 835-849, 2001.
Sasaki, et al., “short Arm Region of Laminin-5 γ2 Chain: Structure, Mechanism of Processing and Binding to Heparin and Proteins”,Journal of Molecular Biology, 314: 751-763, 2001.
Alnabbas, et al., “Elevated Laminin Concentrations in Lung Secretions of Preterm Infants Supported by Mechanical Ventilation are Correlated with Radiographic Abnormalities”,The Journal of Pediatrics, 131(4): 555-560, 1997.
Kropf, et al., “The Prognostic Value of Extracellular Matrix Component Concentrations in Serum During Treatment of Adult Respiratory Distress Syndrome with Extracorporeal CO2Removal”,Eur. J. Clin. Chem. Clin. Biochem., 29: 805-812, 1991.
Nebot, et al., “Laminin 5 in the Human Thymus: Control of T Cell Proliferation via α6β4Integrins”,The Journal of Cell Biology, 144(3): 563-574, 1999.
Fukushima, et al., “Integrin α3β1-Mediated Interaction with Laminin-5 Stimulates Adhesion, Migration and Invasion of Malignant Glioma Cells”,Int. J. Cancer, 76: 63-72, 1998.
Skyldberg, et al., “Laminin-5 as a Marker of Invasiveness in Cervical Lesions”,Journal of the National Cancer Institute, 91(21): 1882-1887, 1999.
Moriya, et al., “Increased Expression of Laminin-5 and Its Prognostic Significance in Lung Adenocarcinomas of Small Size”,Cancer, 91(6): 1129-1141, 2001.

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