Reagent for detecting non-A, non-B viral hepatitis (NANBH) and a

Details Reagent for detecting non-A, non-B viral hepatitis (NANBH) and a Reagent for detecting non-A, non-B viral hepatitis (NANBH) and a

1987-04-07

1989-10-03

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435810, 436513, 436531, 436820, 436808, 422 61, G01N 33569, G01N 33535

Patent

active

048716596

ABSTRACT:
Anti-NANBH (anti-non-A, non-B hepatitis) antibody comprises IgM isolated from sera of monkeys artificially infected with extracts of feces from patients known to be suffering from epidemic NANB hepatitis. A process for isolating an antibody of this type is provided. A reagent for detecting epidemic NANB hepatitis comprises the anti-NANBH IgM fixed to a solid support. The reagent is useful for diagnosing epidemic NANB viral hepatitis by forming an immunological complex between the anti-NANBH IgM and antigen in a fecal extract from a patient being diagnosed, and then incubating the immunological complex with enzyme-labeled IgG from serum of a human convalescing from epidemic NANBH. The complex is detected by developing the enzyme.

REFERENCES:
patent: 4464474 (1984-08-01), Coursaget
patent: 4535057 (1985-08-01), Dreesman
patent: 4702909 (1987-10-01), Villarejos
patent: 4717654 (1988-01-01), Savoca
Wong et al., Epidemic and Endemic Hepatitis in India: Evidence for a Non-A, Non-B Hepatitis Virus Aetiology, Lancet 1980; 2:876-879.
Kane et al., Epidemic Non-A, Non-B Hepatis in Nepal, JAMA 1984; vol. 252, pp. 3140-3145.

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