Reagent composition for fecal occult blood tests

Details Reagent composition for fecal occult blood tests Reagent composition for fecal occult blood tests

1988-03-28

1990-07-17

Hil, Jr., Robert J.

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

435 28, 436904, G01N 2178, G01N 3372, C12Q 128

Patent

active

049421328

ABSTRACT:
Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromagen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.

REFERENCES:
patent: 4017261 (1977-04-01), Svoboda et al.
patent: 4481295 (1984-11-01), Habenstein
patent: 4556640 (1985-12-01), Gantzer
patent: 4596770 (1986-06-01), Parham et al.

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