Reagent composition, dry element and method for determination of

Details Reagent composition, dry element and method for determination of Reagent composition, dry element and method for determination of

1984-04-09

1985-10-22

Turk, Arnold

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-n

422 56, 422 57, 436170, G01N 3352, G01N 3372

Patent

active

045489050

ABSTRACT:
A reagent composition, dry analytical element and a method of using same to determine total bilirubin in aqueous liquids are disclosed. The reagent composition comprises a diazonium salt, or reagents capable of producing a diazonium salt when contacted with water, and 3,3-dimethylglutaric acid or a salt thereof present in an amount effective to buffer the composition at a pH of about 3.5 or less when the composition is contacted with a 2 .mu.L sample of pooled human serum. The composition and elements described herein provide a means to eliminate the effect of an undetermined interferent which is either preformed or formed in situ in diazo-based total bilirubin determinations of biological fluids (e.g. uremic serum).

REFERENCES:
patent: 3511607 (1970-05-01), Green
patent: 3825411 (1974-07-01), Morin
patent: 3880588 (1975-04-01), Rittersdorf et al.
patent: 4038031 (1977-07-01), Lam
patent: 4069017 (1978-01-01), Wu et al.
patent: 4098574 (1978-07-01), Dappen
patent: 4338095 (1982-07-01), Wu
patent: 4468467 (1984-08-01), Babb et al.
Dappen et al., Clin. Chem., 29(1), pp. 37-41, (1983).
Fundamentals of Clinical Chemistry, Tietz (Ed.), W. B. Saunders Co., Philadelphia, pp. 755-760, (1970).
Malloy et al., J. Biol. Chem., 119, p. 481, (1937).

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